由新型严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)引起的COVID-19,迅速传播到世界各地,构成全球健康问题。持续的流行使得有必要为感染SARS-CoV-2的患者开发新的药物和潜在的疗法。疫苗接种和药物开发的进展,没有预防性疫苗接种,迄今为止,已经开发了针对SARS-CoV-2感染的可行疗法。因此,需要进行更多的研究,以找到解决这一毁灭性状况的长期解决方案。正在进行临床研究以确定从海洋物种起始材料回收或合成的生物活性化合物的功效。本研究的重点是海洋来源的植物化学物质的抗SARS-CoV-2潜力,已经在计算机上进行了研究,在体外,和体内模型来确定它们的有效性。海洋生物活性物质,如类黄酮,单宁,生物碱,萜类化合物,肽,凝集素,多糖,和脂质,可以影响SARS-CoV-2在病毒颗粒的渗透和进入细胞,病毒核酸的复制,和病毒体从细胞中释放;它们还可以作用于宿主的细胞靶标。COVID-19已被证明对海洋资源产生的几种污染物具有抗性。本文对作为海洋药物的各种海洋资源及其治疗SARS-CoV-2的潜力进行了概述和总结。我们讨论了许多天然化合物作为从天然来源产生的海洋药物,用于治疗COVID-19和控制当前的大流行情景。
COVID-19, which is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread over the world, posing a global health concern. The ongoing epidemic has necessitated the development of novel drugs and potential therapies for patients infected with SARS-CoV-2. Advances in vaccination and medication development, no preventative vaccinations, or viable therapeutics against SARS-CoV-2 infection have been developed to date. As a result, additional research is needed in order to find a long-term solution to this devastating condition. Clinical studies are being conducted to determine the efficacy of bioactive compounds retrieved or synthesized from marine species starting material. The present study focuses on the anti-SARS-CoV-2 potential of marine-derived phytochemicals, which has been investigated utilizing in in silico, in vitro, and in vivo models to determine their effectiveness. Marine-derived biologically active substances, such as flavonoids, tannins, alkaloids, terpenoids, peptides, lectins, polysaccharides, and lipids, can affect SARS-CoV-2 during the viral particle\'s penetration and entry into the cell, replication of the viral nucleic acid, and virion release from the cell; they can also act on the host\'s cellular targets. COVID-19 has been proven to be resistant to several contaminants produced from marine resources. This paper gives an overview and summary of the various marine resources as marine drugs and their potential for treating SARS-CoV-2. We discussed at numerous natural compounds as marine drugs generated from natural sources for treating COVID-19 and controlling the current pandemic scenario.