PDF(Pubmed)
Abstract：
Anticancer peptides are short and structurally heterogeneous aminoacidic chains, which display selective cytotoxicity mostly against tumor cells, but not healthy cells, based on their different cell surface properties. Their anti-tumoral activity is carried out through interference with intracellular homeostasis, such as plasmalemma integrity, cell cycle control, enzymatic activities and mitochondrial functions, ultimately acting as angiogenesis-, drug resistance- and metastasis-inhibiting agents, immune stimulators, differentiation inducers and necrosis or extrinsic/intrinsic apoptosis promoters. The marine environment features an ever-growing level of biodiversity, and seas and oceans are poorly exploited mines in terms of natural products of biomedical interest. Adaptation processes to extreme and competitive environmental conditions led marine species to produce unique metabolites as a chemical strategy to allow inter-individual signalization and ensure survival against predators, infectious agents or UV radiation. These natural metabolites have found broad use in various applications in healthcare management, due to their anticancer, anti-angiogenic, anti-inflammatory and regeneration abilities. The aim of this review is to pick selected studies that report on the isolation of marine animal-derived peptides and the identification of their anticancer activity in in vitro cultures of cancer cells, and list them with respect to the taxonomical hierarchy of the source organism.
摘要：
抗癌肽是短且结构异质的氨基酸链，主要针对肿瘤细胞显示选择性细胞毒性，但不是健康的细胞，基于它们不同的细胞表面特性。它们的抗肿瘤活性是通过干扰细胞内稳态来进行的，如浆膜的完整性，细胞周期控制，酶活性和线粒体功能，最终充当血管生成-，耐药和转移抑制剂，免疫刺激剂,分化诱导剂和坏死或外在/内在凋亡启动子。海洋环境的生物多样性水平不断提高，就生物医学感兴趣的天然产物而言，海洋和海洋是开采不足的地雷。适应极端和竞争性环境条件的过程导致海洋物种产生独特的代谢物，作为一种化学策略，允许个体间的信号传递并确保抵抗捕食者的生存，传染剂或紫外线辐射。这些天然代谢物已广泛用于医疗保健管理的各种应用中，由于它们的抗癌作用，抗血管生成，抗炎和再生能力。这篇综述的目的是选择一些研究，这些研究报告了海洋动物衍生肽的分离及其在癌细胞体外培养物中的抗癌活性的鉴定，并根据源生物的分类等级列出它们。
