PDF(Pubmed)
Abstract：
Inflammation is a defense mechanism of the body in response to harmful stimuli such as pathogens, damaged cells, toxic compounds or radiation. However, chronic inflammation plays an important role in the pathogenesis of a variety of diseases. Multiple anti-inflammatory drugs are currently available for the treatment of inflammation, but all exhibit less efficacy. This drives the search for new anti-inflammatory compounds focusing on natural resources. Marine organisms produce a broad spectrum of bioactive compounds with anti-inflammatory activities. Several are considered as lead compounds for development into drugs. Anti-inflammatory compounds have been extracted from algae, corals, seaweeds and other marine organisms. We previously reviewed anti-inflammatory compounds, as well as crude extracts isolated from echinoderms such as sea cucumbers, sea urchins and starfish. In the present review, we evaluate the anti-inflammatory effects of compounds from other marine organisms, including macroalgae (seaweeds), marine angiosperms (seagrasses), medusozoa (jellyfish), bryozoans (moss animals), mollusks (shellfish) and peanut worms. We also present a review of the molecular mechanisms of the anti-inflammatory activity of these compounds. Our objective in this review is to provide an overview of the current state of research on anti-inflammatory compounds from marine sources and the prospects for their translation into novel anti-inflammatory drugs.
摘要：
炎症是机体对病原体等有害刺激的防御机制，受损细胞,有毒化合物或辐射。然而,慢性炎症在多种疾病的发病机制中起着重要作用。目前有多种抗炎药可用于治疗炎症，但都表现出较少的功效。这推动了对专注于自然资源的新型抗炎化合物的寻找。海洋生物产生具有抗炎活性的广谱生物活性化合物。几种被认为是开发成药物的先导化合物。已经从藻类中提取了抗炎化合物，珊瑚,海藻和其他海洋生物。我们以前回顾了抗炎化合物，以及从海参等棘皮动物中分离出的粗提物，海胆和海星.在本次审查中，我们评估了其他海洋生物化合物的抗炎作用，包括大型藻类（海藻），海洋被子植物（海草），水母（水母），苔藓动物（苔藓动物），软体动物（贝类）和花生虫。我们还对这些化合物的抗炎活性的分子机制进行了综述。我们在这篇综述中的目的是概述海洋来源的抗炎化合物的研究现状以及将其转化为新型抗炎药物的前景。
