海洋天然产物是一个有眼光的领域,可以寻找未来一代的药物来治疗一系列疾病。同时,癌症在世界各地变得越来越普遍,死亡的可能性正在上升。手术,辐射,化疗是全世界癌症治疗的支柱,但是它们广泛的副作用限制了它们的疗效。寻求低毒性的海洋药物来预防和治疗癌症是目前研究人员的研究重点之一。褐藻多糖,藻类硫酸多糖,是一种有效的癌症治疗先导候选药物,这意味着需要更多的研究。褐藻糖胶是一种多才多艺的,无毒的海洋来源的杂多糖,由于其有益的生物学特性和安全性而备受关注。岩藻依聚糖已被证明具有多种常规生物活性,如抗病毒,抗氧化剂,和免疫调节特性,最近还发现了针对多种恶性肿瘤的抗癌活性。岩藻多糖通过促进细胞周期停滞和凋亡抑制肿瘤发生,阻断转移和血管生成,和调节生理信号分子。这篇综述汇编了分子和细胞方面,岩藻依聚糖作为天然海洋抗癌剂的免疫调节和抗癌作用。来自Eckloniacava的特定岩藻依聚糖和膜状多糖,海带,岩藻,黄芪,夜蛾,本文讨论了脆弱的Codium作为潜在的抗癌海洋药物。
Marine natural products are a discerning arena to search for the future generation of medications to treat a spectrum of ailments. Meanwhile, cancer is becoming more ubiquitous over the world, and the likelihood of dying from it is rising. Surgery, radiation, and chemotherapy are the mainstays of cancer treatment worldwide, but their extensive side effects limit their curative effect. The quest for low-toxicity marine drugs to prevent and treat cancer is one of the current research priorities of researchers. Fucoidan, an algal sulfated polysaccharide, is a potent therapeutic lead candidate against cancer, signifying that far more research is needed. Fucoidan is a versatile, nontoxic marine-origin heteropolysaccharide that has received much attention due to its beneficial biological properties and safety. Fucoidan has been demonstrated to exhibit a variety of conventional bioactivities, such as antiviral, antioxidant, and immune-modulatory characteristics, and anticancer activity against a wide range of malignancies has also recently been discovered. Fucoidan inhibits tumorigenesis by prompting cell cycle arrest and apoptosis, blocking metastasis and angiogenesis, and modulating physiological signaling molecules. This
review compiles the molecular and cellular aspects, immunomodulatory and anticancer actions of fucoidan as a natural marine anticancer agent. Specific fucoidan and membranaceous polysaccharides from Ecklonia cava, Laminaria japonica, Fucus vesiculosus, Astragalus, Ascophyllum nodosum, Codium fragile serving as potential anticancer marine drugs are discussed in this
review.