PDF(Pubmed)
Abstract：
Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure-activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s42995-021-00101-2.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s42995-021-00101-2.
摘要：
来自海洋微生物的天然产物作为用于药物发现的新化合物实体的潜在资源受到了极大的关注。独特的海洋环境为我们带来了一大批具有抗肿瘤等丰富生物功能的含硫天然产物,抗生素,抗炎和抗病毒活性。我们回顾了从海洋微生物中分离出的所有484种含硫天然产物（非硫酸化），其中59.9%是硫醚，29.8％是含噻唑/噻唑啉的化合物，10.3％是亚砜，砜,硫酯和许多其他。进一步讨论了133个化合物的构效关系，行动机制,生物合成，和可吸毒性。这是自1987年1月以来对海洋微生物含硫天然产物进行的第一次系统综述,至2020年12月。
■在线版本包含补充材料，可在10.1007/s42995-021-00101-2获得。
■在线版本包含补充材料，可在10.1007/s42995-021-00101-2获得。
