{Reference Type}: Journal Article
{Title}: The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).
{Author}: Hai Y;Wei MY;Wang CY;Gu YC;Shao CL;
{Journal}: Mar Life Sci Technol
{Volume}: 3
{Issue}: 4
{Year}: 2021 Nov
{Factor}: 5
{DOI}: 10.1007/s42995-021-00101-2
{Abstract}: Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure-activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.<BR><B>UNASSIGNED: </B>The online version contains supplementary material available at 10.1007/s42995-021-00101-2.