PDF(Pubmed)
Abstract：
Transition metal catalysis has contributed to the discovery of novel methodologies and the preparation of natural products, as well as new chances to increase the chemical space in drug discovery programs. In the case of marine drugs, this strategy has been used to achieve selective, sustainable and efficient transformations, which cannot be obtained otherwise. In this perspective, we aim to showcase how a variety of transition metals have provided fruitful couplings in a wide variety of marine drug-like scaffolds over the past few years, by accelerating the production of these valuable molecules.
摘要：
过渡金属催化有助于新方法的发现和天然产物的制备，以及增加药物发现计划中化学空间的新机会。在海洋药物的情况下，这一策略被用来实现选择性，可持续和有效的转型，否则无法获得。从这个角度来看,我们的目标是展示在过去几年中，各种过渡金属如何在各种类似海洋药物的支架中提供了富有成效的连接，通过加速这些有价值的分子的生产。
