我们利用Ischia岛CastelloAragonese的火山CO2喷口作为天然实验室,研究降低pH/升高CO2对肉质褐藻SargassumvulgareC.Agardh提取物生物活性的影响。我们分析了碳水化合物的含量,抗氧化能力,抗菌,抗真菌药,抗原生动物,在酸化部位生长的藻类的抗癌特性和抗诱变潜力(pH〜6.7)以及在附近控制部位LaccoAmeno生长的藻类的抗癌特性(pH〜8.1)。本研究的结果表明,酸化部位的藻类种群中多糖岩藻依聚糖和藻酸盐的水平较高。总的来说,来自酸化部位的藻类种群的提取物显示出更高的抗氧化能力,抗脂质过氧化,抗菌,抗真菌药,抗原生动物,与对照人群相比,抗癌活性和抗诱变潜力。酸化群体中增加的生物活性可能是由于藻类和/或相关微生物群落的生物活性化合物水平升高。在这个快照研究中,我们进行了生物活性测定,但未对推测的生物活性化合物的化学性质和来源进行表征.然而,在酸化海洋中观察到的S.vulgare药用特性的改善为未来的海洋药物发现提供了有希望的基础。
We utilized volcanic CO2 vents at Castello Aragonese off Ischia Island as a natural laboratory to investigate the effect of lowered pH/elevated CO2 on the bioactivities of extracts from fleshy brown algae Sargassum vulgare C. Agardh. We analysed the carbohydrate levels, antioxidant capacity, antibacterial, antifungal, antiprotozoal, anticancer properties and antimutagenic potential of the algae growing at the acidified site (pH ∼ 6.7) and those of algae growing at the nearby control site Lacco Ameno (pH∼8.1). The results of the present
study show that the levels of polysaccharides fucoidan and alginate were higher in the algal population at acidified site. In general, extracts for the algal population from the acidified site showed a higher antioxidant capacity, antilipidperoxidation, antibacterial, antifungal, antiprotozoal, anticancer activities and antimutagenic potential compared to the control population. The increased bioactivity in acidified population could be due to elevated levels of bioactive compounds of algae and/or associated microbial communities. In this snapshot
study, we performed bioactivity assays but did not characterize the chemistry and source of presumptive bioactive compounds. Nevertheless, the observed improvement in the medicinal properties of S. vulgare in the acidified oceans provides a promising basis for future marine drug discovery.