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Abstract：
Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms. The sponge\'s secondary metabolites demonstrated various bioactivities and potential pharmacological properties. This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro. The review was performed in accordance with PRISMA guidelines. The main inclusion criterion for analysis was articles with identification of compounds from terpene classes that demonstrate antioxidant activity in vitro. Searching in three different databases, two hundred articles were selected. After screening abstracts, titles and evaluating for eligibility of manuscripts 14 articles were included. The most performed analyzes to detect antioxidant activity were scavenging activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) and measurement of intracellular reactive oxygen species (ROS). It was possible to identify 17 compounds of the terpene class with pronounced antioxidant activity in vitro. Scientific evidence of the studies included in this review was accessed by the GRADE analysis. Terpenes play an important ecological role, moreover these molecules have a pharmaceutical and industrial application.
摘要：
海洋生物多样性已成为来自不同海洋生物的生物活性化合物和次生代谢物的非常有希望的资源。海绵的次生代谢产物表现出多种生物活性和潜在的药理特性。这篇系统的文献综述侧重于海洋海绵体外抗氧化潜力方面取得的进展。审查是根据PRISMA指南进行的。分析的主要纳入标准是鉴定出具有体外抗氧化活性的萜类化合物的文章。在三个不同的数据库中搜索，两百篇文章被选中。筛选摘要后，标题和手稿资格评估包括14篇文章。检测抗氧化活性的最多的分析是清除活性2,2-二苯基-1-吡啶酰肼（DPPH）和细胞内活性氧（ROS）的测量。有可能在体外鉴定出17种具有明显抗氧化活性的萜类化合物。GRADE分析获得了本综述中包含的研究的科学证据。萜烯在生态方面发挥着重要作用,此外，这些分子具有药物和工业应用。
