%0 Journal Article
%T The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).
%A Hai Y
%A Wei MY
%A Wang CY
%A Gu YC
%A Shao CL
%J Mar Life Sci Technol
%V 3
%N 4
%D 2021 Nov
%M 37073258
%F 5
%R 10.1007/s42995-021-00101-2
%X Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure-activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.<BR><B>UNASSIGNED: </B>The online version contains supplementary material available at 10.1007/s42995-021-00101-2.