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Abstract：
The effects of hypnotics on descriptive and functional aspects of electrophysiological sleep parameters are assessed in this report. Because of the arbitrary definition of some of the criteria underlying the conventional sleep stage scoring procedure, computer-aided methods of EEG analysis have become increasingly important for recording and interpreting pharmacological effects on sleep. Of particular interest are the changes of EEG slow-wave activity, since this parameter varies as a function of prior sleep and waking. Several types of interaction between hypnotics and sleep regulation are discussed, some recent pharmacological developments are highlighted, and some common problems in clinical trials are specified.
摘要：
本报告评估了催眠药对电生理睡眠参数的描述性和功能方面的影响。由于传统睡眠阶段评分程序的某些标准的任意定义，计算机辅助脑电图分析方法对于记录和解释对睡眠的药理作用变得越来越重要。特别感兴趣的是脑电图慢波活动的变化，因为该参数作为先前睡眠和清醒的函数而变化。讨论了催眠药与睡眠调节之间的几种类型的相互作用，最近的一些药理学发展被强调，并指出了临床试验中的一些常见问题。
