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Abstract：
Repeated administration of flurazepam reduced stage 4 sleep (high delta-wave concentration) but produced a greater increase in stage 2 duration so that total sleep time was increased. Computer analysis revealed that the increased amount of stage 2 (low delta-wave concentration) sleep provided a number and duration of delta waves sufficient to offset the loss of delta activity in stage 4. However, the amplitude of the average delta wave was reduced. These results demonstrate the value of direct quantification of delta-wave activity, the variable that underlies visual classification of slow-wave sleep into stages 2 to 4. They also give rise to new hypotheses regarding the relative absence of side effects in spite of profound stage 4 suppression by flurazepam and the mechanisms by which total sleep time is increased by this drug.
摘要：
氟西泮的重复给药减少了第4阶段的睡眠（高δ波浓度），但在第2阶段的持续时间中产生了更大的增加，从而增加了总的睡眠时间。计算机分析显示，第2阶段（低δ波集中）睡眠量的增加提供了足以抵消第4阶段δ活动损失的δ波的数量和持续时间。然而,平均δ波的振幅减小。这些结果证明了直接量化δ波活动的价值，作为慢波睡眠视觉分类的基础的变量，分为2至4阶段。它们还提出了新的假设，即尽管氟拉西泮对第4阶段有深刻的抑制作用，但相对没有副作用，以及该药物增加总睡眠时间的机制。
