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Abstract：
Eleven young adult subjects were briefly awakened after each minute of electroencephalographic-defined sleep for 2 consecutive nights after undisturbed laboratory adaptation and baseline nights. Two undisturbed recovery nights followed disruption nights. On disruption nights, subjects were awakened with an audiometer and signaled the awakening by subjective rating of sleep state or button push response. The disruption procedure resulted in severely fragmented sleep with only very small amounts of slow-wave and REM sleep. Total sleep time was reduced by approximately 1 h on each night. Arousal threshold increased 56 dB across the disruption nights. Following disruption, subjects performed more poorly and rated themselves sleepier than on baseline. The level of decline was similar to that seen after periods of total sleep loss of 40-64 h. Recovery sleep was also similar to that seen after total sleep loss. It was concluded that periodic disruption of sleep, perhaps by destroying sleep continuity, quickly results in impaired function. These data may help explain function loss in severe sleep apneics.
摘要：
在不受干扰的实验室适应和基线夜晚之后，连续2个晚上，在脑电图定义的每分钟睡眠后，短暂唤醒了11名年轻的成年受试者。中断之夜之后是两个未受干扰的恢复之夜。在中断的夜晚，受试者用听力计唤醒，并通过睡眠状态或按钮按压反应的主观评分来表示唤醒。中断过程导致严重的零散睡眠，只有非常少量的慢波和REM睡眠。每晚总睡眠时间减少约1小时。在整个中断之夜，唤醒阈值增加了56dB。中断后，与基线相比，受试者的表现更差，并且对自己的睡眠评分更高。下降的水平与40-64小时的总睡眠不足后观察到的水平相似。恢复睡眠也与总睡眠不足后观察到的睡眠相似。结论是周期性的睡眠中断，也许是通过破坏睡眠的连续性，很快导致功能受损。这些数据可能有助于解释严重睡眠呼吸暂停症的功能丧失。
