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Abstract：
Performance measures were compared to the multiple sleep latency test (MSLT) as indices to assess tolerance to the residual effects of benzodiazepine hypnotics during repeated nightly administration. Twelve healthy, normal sleepers received flurazepam 30 mg, temazepam 30 mg, and placebo for nine nights in a repeated measures, Latin-square design with 19 nights of recovery separating the treatments. As compared to placebo, both drugs altered sleep stage parameters in the early (nights 1-2) and late (nights 8-9) phases of the study. Hypnotic effects were found for both drugs in the early phase, but diminished for both in the late phase. The subjects\' performance the next day was disrupted following treatment with flurazepam, but not with temazepam, during the early phase. Mean sleep latency on the MSLT was reduced by both drugs during the early phase. During the late phase, flurazepam did not disrupt performance but still affected the MSLT. Temazepam affected neither index the next day during the late phase.
摘要：
将性能测量值与多次睡眠潜伏期测试（MSLT）进行比较，作为评估夜间重复给药期间对苯二氮卓催眠药残留作用的耐受性的指标。十二健康，正常睡眠者服用氟西泮30毫克，替马西泮30毫克，和安慰剂九个晚上在一个重复的措施，拉丁广场设计与19个晚上的恢复分开的治疗。与安慰剂相比，两种药物在研究的早期(1-2晚)和晚期(8-9晚)改变了睡眠阶段参数.在早期发现了两种药物的催眠作用，但在后期两者都有所减少。受试者第二天的表现在氟拉西泮治疗后中断，但不是用替马西泮,在早期阶段。在早期阶段，两种药物都降低了MSLT的平均睡眠潜伏期。在后期阶段,氟拉西泮没有破坏性能，但仍然影响MSLT。在后期的第二天，替马西m均未影响指数。
