PDF(Sci-hub)
Abstract：
Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.
摘要：
清晨失眠，在药物之夜的最后几个小时，清醒度显著增加，发生在每晚服用苯二氮卓催眠药1或2周后，消除半衰期短，当耐受性开始发展时。清晨失眠可能是反弹失眠的一种变体，因此对苯二氮卓类药物具有特异性，或者它可能发生与任何迅速消除镇静催眠剂。
