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Abstract：
Eight males were studied during 27 weeks, including two periods of five weeks during which they received clinical doses of sodium amylobarbitone and benzoctamine. Substitution of placebo for either drug caused raised anxiety and impairment of mental concentration. The drugs reduced restlessness during sleep and reduced paradoxical sleep. By the fifth week of sodium amylobarbitone, although sleep was still less restless in the early night it was more restless than normal in the late night.Blood samples were taken half-hourly during sleep by indwelling venous catheter. Plasma growth hormone concentration was little affected during drug administration but rose temporarily after withdrawal. There was a reduction of plasma corticosteroid concentration during sleep throughout administration of the drugs and a rebound above normal during the first withdrawal week.
摘要：
在27周内研究了8只雄性,包括为期五周的两个时期，在此期间他们接受了临床剂量的淀粉巴比妥钠和苯并辛胺。用安慰剂代替两种药物都会引起焦虑和精神集中障碍。这些药物减少了睡眠期间的躁动，并减少了矛盾的睡眠。到第五周的时候,尽管在深夜睡眠仍然不那么不安，但在深夜却比正常人更加不安。在睡眠期间每半小时通过留置静脉导管采集血液样本。给药期间血浆生长激素浓度几乎没有影响，但停药后暂时升高。在整个药物给药过程中，睡眠期间血浆皮质类固醇浓度降低，并且在第一个戒断周内反弹高于正常水平。
