Abstract：
In this research, a quantitative study of the EEG from 5 subjects permitted a detailed analysis of the effect of 30 mg of flurazepam administered over 7 nights. Four placebo baseline nights and 3 placebo withdrawal nights were also recorded. For 4 of the subjects, a nondrug and nonplacebo follow-up record was obtained 4 to 6 weeks later. The subjects were 4 females, 1 male, age range 23-42. All complained of either sleep onset greater than 45 min, sleep length of less than 6 h, or two or more sleep awakenings. Compressed spectral analysis yielded a computer-generated somnogram on each of the 15 nights of sleep, and an automated spindle detector was used to count and measure the duration of spindle bursts with frequencies of 12.25-15.5 c/sec on baseline nights 3 and 4, drug nights 1, 2, 3 and 7, on the 3rd withdrawal night, and on the 4-6 week followup record. K-complexes were scored visually on the 4th baseline and 7th drug nights. There were no significant differences in spindle rate per minute among baseline nights and the follow-up record. By the 2nd drug night, spindle rate had significantly increased over the baseline rate. Linear contrast analysis indicated there was a significant increase of spindle rate over drug nights. All 5 subjects showed this pattern of increase. In contrast to the increase in spindle activity, the rate per minute of K-complexes significantly decreased during drug administration.
摘要：
在这项研究中,对5名受试者的EEG进行了定量研究，从而可以详细分析在7个晚上服用30mg氟西泮的效果。还记录了4个安慰剂基线夜晚和3个安慰剂戒断夜晚。对于四个科目，4~6周后获得非药物和非安慰剂随访记录.受试者为4位女性,1男,年龄范围23-42。所有患者均抱怨睡眠发作超过45分钟，睡眠时间少于6小时，或两个或更多的睡眠觉醒。压缩的频谱分析在15个晚上的睡眠中产生了计算机生成的睡眠图，在第3个戒断之夜，第1、2、3和7个晚上，使用自动纺锤体检测器来计数和测量频率为12.25-15.5c/sec的纺锤体爆发的持续时间，以及4-6周的随访记录。在第4个基线和第7个药物之夜对K-复合物进行视觉评分。在基线夜晚和随访记录之间，每分钟的纺锤率没有显着差异。到第二个吸毒之夜，纺锤率显著高于基线率.线性对比分析表明，在药物之夜，纺锤体速率显着增加。所有5名受试者都显示出这种增加模式。与纺锤体活动的增加相反，在给药过程中，每分钟K复合物的速率显着降低。
