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Abstract：
To test further the conclusions of preliminary reports that regular use of a rapidly-eliminated hypnotic might cause daytime anxiety, 82 women and 38 men, mean age 53, who claimed to be poor sleepers, took a capsule nightly for 45 nights. On 25 consecutive nights the capsule contained triazolam 0.5 mg (40 subjects), lormetazepam 2 mg (40 subjects) or continued placebo (40 subjects). Both drugs improved sleep, but compared with placebo or lormetazepam-takers, triazolam-takers became more anxious on self-ratings, were judged more often to have had a bad response by an observer, more often wrote down complaints of distress, and suffered weight loss. After about 10 days of regular triazolam they tended to develop panics and depression, felt unreal, and sometimes paranoid. The very short life of triazolam, leading to daytime withdrawal symptoms, may account for some of the observations, but enhancement of benzodiazepine inverse agonist activity is also hypothesized.
摘要：
为了进一步检验初步报告的结论，即定期使用快速消除的催眠药可能会导致白天焦虑，82名女性和38名男性,平均年龄53岁，自称睡眠不足，每晚服用胶囊45个晚上。在连续25个晚上的胶囊含有三唑仑0.5毫克（40名受试者），洛美西泮2mg（40名受试者）或继续安慰剂（40名受试者）。两种药物都能改善睡眠，但与安慰剂或服用氯美地西相比，三唑仑的接受者对自我评价变得更加焦虑，更经常被观察者判断为反应不佳，更经常写下痛苦的抱怨，体重下降。经过大约10天的常规三唑仑，他们倾向于发展恐慌和抑郁症，感觉不真实，有时是偏执狂。三唑仑的寿命很短,导致白天戒断症状，可以解释一些观察结果，但也假设苯二氮卓类药物反向激动剂活性增强。
