关键词： (CBF1/Su(H)/Lag-1) transcription factor complex ADAM AMD AP-1 Autoimmunity B-cell lymphoma 2 Bcl-2 CCL CCP CD46 CD46 cytoplasmic domain 1 or 2 CSL CYT-1 or CYT-2 Complement DC DLG4 DLL ERK1/2 FLT3 FLT3L FMS-related tyrosine kinase 3 FMS-related tyrosine kinase 3 ligand G protein-coupled receptor G protein-coupled receptor kinase GAS GATA3 GOPC GPCR GRK GSK3β GTP Group A Streptococcus pyogenes ICER/CREM IFN IL IPEX IS Infection JAK JNK Janus kinase LAT LDL receptor-related protein LEF LRP Lck MAPK MHC MMP MS MTOC NF-κB NICD NO Notch intracellular domain PGE2 RA RCA SLE SNP SP-1 SPAK STAT STP region Ste20/SPS-1-related kinase T cell receptor T helper cell/response T-bet T-box transcription factor TBX21 T-cell factor/lymphocyte-enhancer-binding factor TCR TER TLR Th Th1 cells Toll-like receptor UT a disintegrin and metalloproteinase aHUS activator protein 1 age-related macular degeneration atypical hemolytic uremic syndrome c-Jun amino-terminal kinase chemokine (C-C motif) ligand complement control protein domain delta-like ligand dendritic cell extracellular signal-regulated protein kinases 1 and 2 glycogen synthase kinase 3β golgi-associated PDZ and coiled-coil motif-containing protein guanine triphosphate human homologue of Discs Large (DLG) Drosophila immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like immunological synapse inducible cAMP early repressor/cAMP response element modulator interferon interleukin linker for activation of T cells lymphocyte-specific protein tyrosine kinase major histocompatibility complex matrix metalloproteinase microtubule organizing centre mitogen-activated protein kinase multiple sclerosis nTreg natural regulatory T cell nitric oxide nuclear factor kappa-light-chain-enhancer of activated B cells prostaglandin E2 regulators of complement activity rheumatoid arthritis serine, threonine, proline-rich region signal transducer and activator of transcription single-nucleotide polymorphism specificity protein 1 systemic lupus erythematosus trans-acting T-cell-specific transcription factor GATA3 transepithelial resistance untranslated region

Mesh ： Complement System Proteins / immunology Humans Immunity, Innate Membrane Cofactor Protein / immunology Signal Transduction

来  源：   DOI：10.1016/j.biocel.2013.09.016   PDF(Sci-hub)

Abstract：
Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4(+) T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose.
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