肥胖目前被认为是大流行的公共卫生问题,并与慢性低度炎症有关。这可能会导致几种慢性疾病和代谢并发症的发展。这项基于人群的横断面研究,与743名巴西成年人一起进行,旨在评估炎症细胞因子与人体测量之间的关联。社会人口学,人体测量学,收集行为和生化变量。按性别分层并校正混杂因素的多元线性回归。在男人中,腰围(WC)与IL-1β(3·52pg/ml;95%CI0·60,6·45)相关,IL-6(6·35pg/ml;95%CI0·35,12·34),IL-8(8·77pg/ml;95%CI2·37,15·17),IL-10(3·09pg/ml;95%CI0·56,5·61),IL12p70(8·31pg/ml;95%CI3·11,13·52)和TNF-α(4·22pg/ml;95%CI0·20,10·48)。腰围:身高比与IL-6(3·21pg/ml;95%CI0·02,6·39)相关。BMI与IL-1β(1·50pg/ml;95%CI0·46,2·34)相关,IL-6(2·97pg/ml;95%CI0·78,5·16),IL-8(4·48pg/ml;95%CI2·21,6·75),IL-10(1·31pg/ml;95%CI0·30,2·31),IL-12p70(3·59pg/ml;95%CI1·24,5·95)和TNF-α(2·00pg/ml;95%CI0·81,3·19)。在女性中,WC与IL-6(5·10pg/ml;95%CI0·68,9·51)和IL-10(4·16pg/ml;95%CI1·26,7·06)相关。BMI与IL-6相关(2·67pg/ml;95%CI0·34,4·99),WHR与TNF-α(2·84pg/ml;95%IC0·86-6·54)相关。结果强调了人体测量评估在临床实践中的重要性,以及制定公共政策和干预措施以减少肥胖患病率的必要性,因此,炎症和可能的代谢并发症。
Obesity is currently considered a public health problem with pandemic proportions and is associated with chronic low-grade inflammation, which can predispose to the development of several chronic diseases and metabolic complications. This cross-sectional population-based study, conducted with 743 Brazilian adults, aimed to evaluate the association between inflammatory cytokines with anthropometric measurements. Socio-demographic, anthropometric, behavioural and biochemical variables were collected. Multiple linear regression stratified by sex and adjusted for confounding factors was performed. In men, waist circumference (WC) was associated with
IL-1β (3·52 pg/ml; 95 % CI 0·60, 6·45),
IL-6 (6·35 pg/ml; 95 % CI 0·35, 12·34),
IL-8 (8·77 pg/ml; 95 % CI 2·37, 15·17),
IL-10 (3·09 pg/ml; 95 % CI 0·56, 5·61), IL12p70 (8·31 pg/ml; 95 % CI 3·11, 13·52) and TNF-α (4·22 pg/ml; 95 % CI 0·20, 10·48). Waist:height ratio was associated with IL-6 (3·21 pg/ml; 95 % CI 0·02, 6·39). BMI was associated with
IL-1β (1·50 pg/ml; 95 % CI 0·46, 2·34),
IL-6 (2·97 pg/ml; 95 % CI 0·78, 5·16),
IL-8 (4·48 pg/ml; 95 % CI 2·21, 6·75),
IL-10 (1·31 pg/ml; 95 % CI 0·30, 2·31),
IL-12p70 (3·59 pg/ml; 95 % CI 1·24, 5·95) and TNF-α (2·00 pg/ml; 95 % CI 0·81, 3·19). In women, WC was associated with
IL-6 (5·10 pg/ml; 95 % CI 0·68, 9·51) and
IL-10 (4·16 pg/ml; 95 % CI 1·26, 7·06). BMI was associated with IL-6 (2·67 pg/ml; 95 % CI 0·34, 4·99), and WHR was associated with TNF-α (2·84 pg/ml; 95 % IC 0·86-6·54). The results highlight the importance of anthropometric assessment in clinical practice and the need to develop public policies and interventions to reduce the prevalence of obesity and, consequently, of inflammation and possible metabolic complications.