■非编码RNA(ncRNA),无法编码蛋白质,通过改变转录和转录后加工参与许多肿瘤的进展。最近的研究揭示了ncRNAs在焦亡中的突出特征,一种与炎症反应有关的非凋亡性程序性细胞破坏。作为抗凋亡蛋白的结果,耐药性逐渐出现,因此,基于焦化性细胞死亡的策略引起了越来越多的关注。我们观察到ncRNAs可能对癌症治疗产生重大影响。化疗,放射治疗,靶向治疗和免疫治疗,通过调节焦亡。
■检索了(2023年12月)有关ncRNAs介导的细胞凋亡的癌症治疗研究的文献。
■ncRNAs调控靶基因的最普遍的机械策略是竞争性内源性RNAs(ceRNA)。此外,某些ncRNAs可以直接与蛋白质相互作用并调节下游基因以诱导焦亡,导致肿瘤生长或抑制。在这次审查中,我们的目标是显示ncRNAs,主要是长链非编码RNA(lncRNAs),微小RNA(miRNA)和环状RNA(circularRNAs),可以作为诊断和预后的潜在生物标志物,并产生新的见解,通过焦亡调节的抗癌策略,用于临床应用。
UNASSIGNED: Non-coding RNAs (ncRNAs), which are incapable of encoding proteins, are involved in the progression of numerous tumors by altering transcriptional and post-transcriptional processing. Recent studies have revealed prominent features of ncRNAs in pyroptosis, a type of non-apoptotic programmed cellular destruction linked to an inflammatory reaction. Drug resistance has arisen gradually as a result of anti-apoptotic proteins, therefore strategies based on pyroptotic cell death have attracted increasing attention. We have observed that ncRNAs may exert significant influence on cancer therapy, chemotherapy, radio- therapy, targeted therapy and immunotherapy, by regulating pyroptosis.
UNASSIGNED: Literatures were searched (December 2023) for studies on cancer therapy for ncRNAs-mediated pyroptotic cell death.
UNASSIGNED: The most universal mechanical strategy for ncRNAs to regulate target genes is competitive endogenous RNAs (ceRNA). Besides, certain ncRNAs could directly interact with proteins and modulate downstream genes to induce pyroptosis, resulting in tumor growth or inhibition. In this
review, we aim to display that ncRNAs, predominantly long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), could function as potential biomarkers for diagnosis and prognosis and produce new insights into anti-cancer strategies modulated by pyroptosis for clinical applications.