Abstract：
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and the third leading cause of cancer-related fatalities. Long non-coding RNAs (lncRNAs) are key regulators of diverse physiological processes and are dysregulated in a wide range of pathophysiological circumstances such as CRC. Studies revealed that aberrant expressions of lncRNAs clearly modulate the expression level of p53 gene in CRC, thereby transactivating multiple downstream pathways. P53 is regarded as a crucial tumor suppressor gene which promotes cell-cycle arrest, DNA repair, senescence or apoptosis in response to cellular stresses. P53 is also mutated in CRC as well as various types of human malignancies. Therefore, lncRNAs interact with the p53 signaling pathway in numerus ways and significantly influence CRC-related processes. The current findings in the investigation of the crosstalk between lncRNAs and the P53 pathway in controlling CRC carcinogenesis, tumor progression, and therapeutic resistance are summarized in the this review. A deeper knowledge of CRC carcinogenesis may also have implications in CRC prevention and treatment through more research.
摘要：
结直肠癌（CRC）是全球最常见的恶性肿瘤之一，也是癌症相关死亡的第三大原因。长链非编码RNA(lncRNA)是不同生理过程的关键调节因子,并且在广泛的病理生理环境如CRC中失调。研究表明，lncRNAs的异常表达明显调节CRC中p53基因的表达水平，从而反式激活多个下游途径。P53被认为是促进细胞周期停滞的关键抑癌基因。DNA修复,响应细胞应激的衰老或凋亡。P53也在CRC以及各种类型的人类恶性肿瘤中突变。因此,lncRNAs以多种方式与p53信号通路相互作用，并显着影响CRC相关过程。目前研究lncRNAs与P53通路在控制CRC癌变中的串扰,肿瘤进展，并对其耐药性进行综述。通过更多的研究，对CRC癌变的更深入了解也可能对CRC的预防和治疗产生影响。
