PDF(Pubmed)
Abstract：
Keratinocytes, the principal epidermal cells, play a vital role in maintaining the structural integrity and functionality of the skin. Beyond their protective role, keratinocytes are key contributors to the process of wound healing, as they migrate to injury sites, proliferate, and generate new layers of epidermis, facilitating tissue repair and remodeling. Moreover, keratinocytes actively participate in the skin\'s immune responses, expressing pattern recognition receptors (PRRs) to detect microbial components and interact with immune cells to influence adaptive immunity. Keratinocytes express a diverse repertoire of signaling pathways, transcription factors, and epigenetic regulators to regulate their growth, differentiation, and response to environmental cues. Among these regulatory elements, long non-coding RNAs (lncRNAs) have emerged as essential players in keratinocyte biology. LncRNAs, including MALAT1, play diverse roles in gene regulation and cellular processes, influencing keratinocyte proliferation, differentiation, migration, and response to environmental stimuli. Dysregulation of specific lncRNAs such as MALAT1 can disrupt keratinocyte homeostasis, leading to impaired differentiation, compromised barrier integrity, and contributing to the pathogenesis of various skin disorders. Understanding the intricate interplay between lncRNAs and keratinocytes offers promising insights into the molecular underpinnings of skin health and disease, with potential implications for targeted therapies and advancements in dermatological research. Hence, our objective is to provide a comprehensive summary of the available knowledge concerning keratinocytes and their intricate relationship with MALAT1.
摘要：
角质形成细胞,主要的表皮细胞，在保持皮肤的结构完整性和功能方面发挥着至关重要的作用。除了他们的保护作用，角质形成细胞是伤口愈合过程的关键贡献者，当它们迁移到受伤部位时，增殖，并产生新的表皮层，促进组织修复和重塑。此外，角质形成细胞积极参与皮肤的免疫反应，表达模式识别受体（PRR）以检测微生物成分并与免疫细胞相互作用以影响适应性免疫。角质形成细胞表达不同的信号通路，转录因子，和表观遗传调节剂来调节它们的生长，分化,以及对环境线索的反应。在这些监管要素中，长链非编码RNA（lncRNAs）已成为角质形成细胞生物学中必不可少的参与者。LncRNAs,包括MALAT1，在基因调控和细胞过程中发挥不同的作用，影响角质形成细胞增殖，分化,迁移,以及对环境刺激的反应。特定lncRNAs如MALAT1的失调可以破坏角质形成细胞的稳态，导致分化受损，屏障完整性受损，并有助于各种皮肤病的发病机理。了解lncRNAs和角质形成细胞之间复杂的相互作用为皮肤健康和疾病的分子基础提供了有希望的见解。对靶向治疗和皮肤病学研究的进步有潜在的影响。因此，我们的目标是提供有关角质形成细胞及其与MALAT1的复杂关系的现有知识的全面总结。
