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Abstract：
Non-coding RNAs (ncRNA) have paved the way to new perspectives on the regulation of gene expression, not only in biology and medicine, but also in associated fields and technologies, ensuring advances in diagnostic means and therapeutic modalities. Critical in this multistep approach are the associations of long non-coding RNA (lncRNA) with diseases and their causal genes in their networks of interactions, gene enrichment and expression analysis, associated pathways, the monitoring of the involved genes and their functional roles during disease progression from one stage to another. Studies have shown that Johne\'s Disease (JD), caused by Mycobacterium avium subspecies partuberculosis (MAP), shares common lncRNAs, clinical findings, and other molecular entities with Crohn\'s Disease (CD). This has been a subject of vigorous investigation owing to the zoonotic nature of this condition, although results are still inconclusive. In this review, on one hand, the current knowledge of lncRNAs in cells is presented, focusing on the pathogenesis of gastrointestinal-related pathologies and MAP-related infections and, on the other hand, we attempt to dissect the associated genes and pathways involved. Furthermore, the recently characterized and novel lncRNAs share common pathologies with IBD and JD, including the expression, molecular networks, and dataset analysis results. These are also presented in an attempt to identify potential biomarkers pertinent to cattle and human disease phenotypes.
摘要：
非编码RNA（ncRNA）为基因表达调控的新观点铺平了道路，不仅在生物学和医学领域，而且在相关领域和技术中，确保诊断手段和治疗方式的进步。这种多步骤方法的关键是长链非编码RNA（lncRNA）与疾病及其相互作用网络中的因果基因的关联。基因富集和表达分析，相关途径，在疾病从一个阶段到另一个阶段的过程中，对相关基因及其功能作用的监测。研究表明，约翰病(JD)，由鸟分枝杆菌亚种副结核（MAP）引起，共享共同的lncRNAs，临床发现，和其他分子实体与克罗恩病（CD）。由于这种情况的人畜共患性质，这是一个积极调查的主题，尽管结果仍然没有定论。在这次审查中,一方面,介绍了细胞中lncRNAs的最新知识，重点关注胃肠道相关病理和MAP相关感染的发病机理，另一方面,我们试图解剖相关的基因和通路。此外，最近表征的和新的lncRNAs与IBD和JD有共同的病理，包括表达式，分子网络，和数据集分析结果。这些也在试图鉴定与牛和人类疾病表型相关的潜在生物标志物中呈现。
