PDF(Pubmed)
Abstract：
The confrontation between humans and bacteria is ongoing, with strategies for combating bacterial infections continually evolving. With the advancement of RNA sequencing technology, non-coding RNAs (ncRNAs) associated with bacterial infections have garnered significant attention. Recently, long ncRNAs (lncRNAs) have been identified as regulators of sterile inflammatory responses and cellular defense against live bacterial pathogens. They are involved in regulating host antimicrobial immunity in both the nucleus and cytoplasm. Increasing evidence indicates that lncRNAs are critical for the intricate interactions between host and pathogen during bacterial infections. This paper emphatically elaborates on the potential applications of lncRNAs in clinical hallmarks, cellular damage, immunity, virulence, and drug resistance in bacterial infections in greater detail. Additionally, we discuss the challenges and limitations of studying lncRNAs in the context of bacterial infections and highlight clear directions for this promising field.
摘要：
人类和细菌之间的对抗正在进行中，对抗细菌感染的策略不断发展。随着RNA测序技术的进步,与细菌感染相关的非编码RNA（ncRNAs）已经引起了极大的关注。最近,长ncRNAs（lncRNAs）已被鉴定为无菌炎症反应和细胞防御的调节因子。它们参与调节细胞核和细胞质中的宿主抗微生物免疫。越来越多的证据表明，lncRNAs对于细菌感染期间宿主和病原体之间复杂的相互作用至关重要。本文着重阐述了lncRNAs在临床标志中的潜在应用，细胞损伤,豁免权,毒力,以及细菌感染中的耐药性。此外,我们讨论了在细菌感染背景下研究lncRNAs的挑战和局限性，并强调了这个有前途的领域的明确方向。
