%0 Journal Article
%T The biological role of lncRNAs in the acute lymphocytic leukemia: An updated review.
%A Ghahramani Almanghadim H
%A Karimi B
%A Poursalehi N
%A Sanavandi M
%A Atefi Pourfardin S
%A Ghaedi K
%J Gene
%V 898
%N 0
%D 2024 Mar 10
%M 38104953
%F 3.913
%R 10.1016/j.gene.2023.148074
%X The cause of leukemia, a common malignancy of the hematological system, is unknown. The structure of long non-coding RNAs (lncRNAs) is similar to mRNA but no ability to encode proteins. Numerous malignancies, including different forms of leukemia, are linked to Lnc-RNAs. It is verified that the carcinogenesis and growth of a variety of human malignancies are significantly influenced by aberrant lncRNA expression. The body of evidence linking various types of lncRNAs to the etiology of leukemia has dramatically increased during the past ten years. Some lncRNAs are therefore anticipated to function as novel therapeutic targets, diagnostic biomarkers, and clinical outcome predictions. Additionally, these lncRNAs may provide new therapeutic options and insight into the pathophysiology of diseases, particularly leukemia. Thus, this review outlines the present comprehension of leukemia-associated lncRNAs.