PDF(Pubmed)
Abstract：
The use of non-coding RNAs (ncRNAs) as drug targets is being researched due to their discovery and their role in disease. Targeting ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is an attractive approach for treating various diseases, such as cardiovascular disease and cancer. This seminar discusses the current status of ncRNAs as therapeutic targets in different pathological conditions. Regarding miRNA-based drugs, this approach has made significant progress in preclinical and clinical testing for cardiovascular diseases, where the limitations of conventional pharmacotherapy are evident. The challenges of miRNA-based drugs, including specificity, delivery, and tolerability, will be discussed. New approaches to improve their success will be explored. Furthermore, it extensively discusses the potential development of targeted therapies for cardiovascular disease. Finally, this document reports on the recent advances in identifying and characterizing microRNAs, manipulating them, and translating them into clinical applications. It also addresses the challenges and perspectives towards clinical application.
摘要：
由于非编码RNA（ncRNA）的发现及其在疾病中的作用，正在研究将其用作药物靶标。靶向ncRNAs，包括microRNAs（miRNAs）和长链非编码RNAs（lncRNAs），是治疗各种疾病的一种有吸引力的方法，比如心血管疾病和癌症。本研讨会讨论了ncRNAs在不同病理条件下作为治疗靶标的现状。关于基于miRNA的药物，这种方法在心血管疾病的临床前和临床检测方面取得了重大进展，传统药物治疗的局限性是显而易见的。基于miRNA的药物的挑战，包括特异性，delivery,和耐受性，将讨论。将探索提高其成功的新方法。此外，它广泛讨论了心血管疾病靶向治疗的潜在发展。最后,本文件报告了鉴定和表征microRNAs的最新进展，操纵他们,并将其转化为临床应用。它还解决了临床应用的挑战和观点。
