Abstract：
The cause of leukemia, a common malignancy of the hematological system, is unknown. The structure of long non-coding RNAs (lncRNAs) is similar to mRNA but no ability to encode proteins. Numerous malignancies, including different forms of leukemia, are linked to Lnc-RNAs. It is verified that the carcinogenesis and growth of a variety of human malignancies are significantly influenced by aberrant lncRNA expression. The body of evidence linking various types of lncRNAs to the etiology of leukemia has dramatically increased during the past ten years. Some lncRNAs are therefore anticipated to function as novel therapeutic targets, diagnostic biomarkers, and clinical outcome predictions. Additionally, these lncRNAs may provide new therapeutic options and insight into the pathophysiology of diseases, particularly leukemia. Thus, this review outlines the present comprehension of leukemia-associated lncRNAs.
摘要：
白血病的病因,血液系统常见的恶性肿瘤，是未知的。长链非编码RNA（lncRNA）的结构与mRNA相似，但没有编码蛋白质的能力。许多恶性肿瘤，包括不同形式的白血病，与Lnc-RNA连接。已证实，lncRNA的异常表达显着影响了多种人类恶性肿瘤的发生和生长。在过去的十年中，将各种类型的lncRNAs与白血病病因联系起来的证据急剧增加。因此，一些lncRNAs有望作为新的治疗靶标发挥作用，诊断生物标志物，和临床结果预测。此外,这些lncRNAs可能为疾病的病理生理学提供新的治疗选择和见解，尤其是白血病。因此，这篇综述概述了目前对白血病相关lncRNAs的理解。
