用于癌症免疫治疗的基于生物响应性免疫增强剂的前药纳米凝胶。
关键词: 5-ALA, 5-aminolevulinic acid 5-FU, 5-fluorouracil ALKP, alkaline phosphatase ALT, alanine aminotransferase APCs, antigen-presenting cells AST, aminotransferase ATP, adenosine triphosphate AUC, area under curves Bioresponsive CLSM, confocal laser scanning microscope CPT-11, irinotecan CRE, creatinine CRT, calreticulin Ce6, chlorin e6 Chemotherapy DAMPs, damage-associated molecular patterns DCs, dendritic cells DDSs, drug delivery systems DLN, draining lymph nodes DM NGs, doxorubicin-based mannose nanogel DOC, docetaxel DOX, doxorubicin DTT, d,l-dithiothreitol Doxorubicin FCM, flow cytometry FDA, Fluorescein diacetate GEM, gemcitabine GSH, glutathione H&E, hematoxylin-eosin HCPT, 10-hydroxy camptothecin HCT, hematocrit HGB, hemoglobin concentration HMGB1, high migrating group box 1 ICB, immune checkpoint blockade ICD, immunogenic cell death ICG, indocyanine Green IHC, immunohistochemistry ITM, immunosuppressive tumor microenvironment Immunogenic cell death Immunotherapy LDH, lactate dehydrogenase LYM, lymphocyte ratio MAN, mannose MCHC, mean corpuscular hemoglobin concentration MCSs, multicellular spheroids MFI, mean fluorescence intensity MPV, mean platelet volume Mannose NGs, nanogels Nanogel OXA, oxaliplatin P18, purpurin 18 PDI, polydispersity index PLT, platelets PTX, paclitaxel Prodrug RBC, red blood cell count RDW, variation coefficient of red blood cell distribution width TAAs, tumor-associated antigens TAM, tumor-associated macrophages TGF-β, transforming growth factor-β TMA, tissue microarrays TME, tumor microenvironment Urea, urea nitrogen WBC, white blood cell count irAEs, immune-related adverse events 5-ALA, 5-aminolevulinic acid 5-FU, 5-fluorouracil ALKP, alkaline phosphatase ALT, alanine aminotransferase APCs, antigen-presenting cells AST, aminotransferase ATP, adenosine triphosphate AUC, area under curves Bioresponsive CLSM, confocal laser scanning microscope CPT-11, irinotecan CRE, creatinine CRT, calreticulin Ce6, chlorin e6 Chemotherapy DAMPs, damage-associated molecular patterns DCs, dendritic cells DDSs, drug delivery systems DLN, draining lymph nodes DM NGs, doxorubicin-based mannose nanogel DOC, docetaxel DOX, doxorubicin DTT, d,l-dithiothreitol Doxorubicin FCM, flow cytometry FDA, Fluorescein diacetate GEM, gemcitabine GSH, glutathione H&E, hematoxylin-eosin HCPT, 10-hydroxy camptothecin HCT, hematocrit HGB, hemoglobin concentration HMGB1, high migrating group box 1 ICB, immune checkpoint blockade ICD, immunogenic cell death ICG, indocyanine Green IHC, immunohistochemistry ITM, immunosuppressive tumor microenvironment Immunogenic cell death Immunotherapy LDH, lactate dehydrogenase LYM, lymphocyte ratio MAN, mannose MCHC, mean corpuscular hemoglobin concentration MCSs, multicellular spheroids MFI, mean fluorescence intensity MPV, mean platelet volume Mannose NGs, nanogels Nanogel OXA, oxaliplatin P18, purpurin 18 PDI, polydispersity index PLT, platelets PTX, paclitaxel Prodrug RBC, red blood cell count RDW, variation coefficient of red blood cell distribution width TAAs, tumor-associated antigens TAM, tumor-associated macrophages TGF-β, transforming growth factor-β TMA, tissue microarrays TME, tumor microenvironment Urea, urea nitrogen WBC, white blood cell count irAEs, immune-related adverse events
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DOI:10.1016/j.apsb.2021.05.016
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