背景:急性冠脉综合征(ACS)的病理生理学涉及血栓和炎症机制。该研究的目的是评估炎症(白细胞计数/白细胞,C反应蛋白/CRP,白细胞介素-6/IL-6)和血小板(血小板计数/血小板,平均血小板体积/MPV,大血小板/LPLT,根据体征和症状的严重程度,ACS患者组中的β-血小板球蛋白/β-TG)生物标志物与无冠状动脉疾病的对照组相比。
方法:研究组包括93名患者,根据ACS的体征和症状的严重程度分为3个亚组。PLT,MPV,LPLT,和白细胞在血液分析仪上测定,使用ELISA方法测量IL-6和β-TG。
结果:在整个ACS患者WBC组中,CRP,IL-6,MPV,和β-TG显著高于对照组。与对照组相比,根据体征和症状的严重程度分析炎症和血小板生物标志物,上述参数也存在统计学上的显著差异.冠状动脉变化的进展与炎症和血小板参数之间没有显着差异。除了CRP浓度。测试的所有炎症参数的AUC相似,然而,最高的AUC显示WBC和CRP。在血小板参数中,最高AUC显示β-TG。
结论:炎症和血小板活化标志物可能与心肌缺血和心肌损伤有关。WBC,CRP和IL-6作为炎症参数,MPV和β-TG作为血小板生物标志物可能是冠状动脉疾病存在的有用指标。
BACKGROUND: Thrombotic and inflammatory mechanisms are involved in the pathophysiology of acute coronary syndrome (ACS). The aim of the study was the evaluation of inflammation (white blood cells count/WBC, C-reactive protein/CRP, interleukin-6/IL-6) and platelet (platelet count/PLT, mean platelet volume/MPV, large platelet/LPLT, beta-thromboglobulin/β-TG) biomarkers in the groups of ACS patients depending on the severity of signs and symptoms and compared to controls without coronary artery disease.
METHODS: The study group included 93 patients categorized into 3 subgroups depending on the severity of signs and symptoms of ACS. PLT, MPV, LPLT, and WBC were determined on hematological analyzer, IL-6 and β-TG were measured using the ELISA method.
RESULTS: In the whole group of ACS patients WBC, CRP, IL-6, MPV, and β-TG were significantly higher as compared to controls. Analyzing the inflammation and platelet biomarkers depending on the severity of signs and symptoms in comparison to controls, statistically significant differences for above-mentioned parameters were also found. There were no significant differences between the advancement of coronary artery changes and inflammation as well as platelet parameters, except for CRP concentrations. The AUCs for all inflammation parameters tested were similar, however the highest AUCs showed WBC and CRP. Among platelet parameters the highest AUC revealed β-TG.
CONCLUSIONS: Markers of inflammation and platelet activation may be associated to myocardial ischemia and myocardial injury. WBC, CRP and IL-6 as inflammation parameters and MPV and β-TG as platelet biomarkers may be useful indicators of the presence of coronary artery disease.