癌症干细胞(CSC)是功能与正常干细胞相似的癌细胞亚群。虽然数量很少,他们能够自我更新,无限扩散,和多方向的分化潜力。此外,CSC具有逃避免疫监视的能力。因此,它们在肿瘤的发生和发展中起着重要作用,它们与肿瘤侵袭密切相关,转移,耐药性,治疗后复发。因此,CSC的特异性靶向可以提高癌症治疗的效率。一系列基于CSC靶向的相应有前途的治疗策略,例如针对CSC利基,CSC信号通路,和CSC线粒体,目前正在开发中。鉴于该领域和纳米技术的快速发展,用于CSC靶向的药物递送系统(DDS)正在被越来越多地开发。在这次审查中,我们总结了以CSC为目标的DDS的进展。此外,我们通过CSC发生和发展过程的主线,突出最新的发展趋势;关于基本原理的一些考虑,优势,并讨论了不同DDS用于CSC靶向治疗的局限性。
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those of normal stem cells. Although few in number, they are capable of self-renewal, unlimited proliferation, and multi-directional differentiation potential. In addition, CSCs have the ability to escape immune surveillance. Thus, they play an important role in the occurrence and development of tumors, and they are closely related to tumor invasion, metastasis, drug resistance, and recurrence after treatment. Therefore, specific targeting of CSCs may improve the efficiency of cancer therapy. A series of corresponding promising therapeutic strategies based on CSC targeting, such as the targeting of CSC niche, CSC signaling pathways, and CSC mitochondria, are currently under development. Given the rapid progression in this field and nanotechnology, drug delivery systems (DDSs) for CSC targeting are increasingly being developed. In this review, we summarize the advances in CSC-targeted DDSs. Furthermore, we highlight the latest developmental trends through the main line of CSC occurrence and development process; some considerations about the rationale, advantages, and limitations of different DDSs for CSC-targeted therapies were discussed.