未经证实:功能性促性腺激素腺瘤(FGA)是产生活性促性腺激素的腺瘤,促卵泡激素或促黄体激素。双垂体腺瘤是个体中发生的2种不同的腺瘤。这份报告旨在介绍一个极为罕见的FGA病例,本身是一种不常见的疾病,与催乳腺瘤同时发生。
未经证实:一名33岁女性出现月经过多,被发现卵巢增大,大型子宫平滑肌瘤,和双颞侧偏盲.最初,促卵泡激素的水平,黄体生成素,雌二醇,催乳素为73.3mIU/mL(中周期峰,2.3-20.9mIU/L),3.74mIU/L(中周期峰值,8.7-76.3mIU/L),1071pg/mL(中周期峰38-649pg/mL),和402ng/mL(2-30ng/mL),分别。垂体磁共振成像显示单个鞍块(2.0×2.2cm)。两个月的卡麦角林不能逆转视野缺损;因此,经蝶窦切除术。2个独立腺瘤的诊断,促性腺激素性和催乳腺瘤,病理证实。
UNASSIGNED:在这种情况下,促性腺激素对高催乳素血症没有抑制作用。尽管在以前的病例中,明显的高泌乳素血症与功能性和临床上无症状的促性腺激腺瘤有关,这是首例证实FGA与乳品腺瘤同时发生的病例.
未经证实:尽管存在高催乳素血症但仍存在促性腺激素水平升高的患者,我们建议考虑FGA。需要进一步的研究来澄清是否存在与促性腺激性腺瘤同时发生的催乳腺瘤的诊断不足。
UNASSIGNED: Functional gonadotroph adenomas (FGAs) are adenomas producing active gonadotropins, follicle-stimulating hormone or luteinizing hormone. Double pituitary adenomas are 2 distinct adenomas occurring in an individual. This report aimed to present an extremely rare case of an FGA, itself an uncommon disorder, co-occurring with a lactotroph adenoma.
UNASSIGNED: A 33-year-old woman presented with menorrhagia and was found to have ovarian enlargement, large uterine leiomyomas, and bitemporal hemianopsia. Initially, the levels of follicle-stimulating hormone, luteinizing hormone, estradiol, and prolactin were 73.3 mIU/mL (midcycle peak, 2.3-20.9 mIU/L), 3.74 mIU/L (midcycle peak, 8.7-76.3 mIU/L), 1071 pg/mL (midcycle peak 38-649 pg/mL), and 402 ng/mL (2-30 ng/mL), respectively. Pituitary magnetic resonance imaging demonstrated a single sellar mass (2.0 × 2.2 cm). Two months of cabergoline did not reverse visual field deficits; therefore, transsphenoidal resection was performed. Diagnosis of 2 separate adenomas, a gonadotroph and lactotroph adenoma, was confirmed on pathology.
UNASSIGNED: In this case, gonadotropins did not suppress in response to hyperprolactinemia. Although marked hyperprolactinemia has been associated with functional and clinically silent gonadotroph adenomas in prior cases, this is the first case to confirm an FGA co-occurring with a lactotroph adenoma.
UNASSIGNED: In patients who present with elevated gonadotropin levels despite hyperprolactinemia, we suggest considering FGA. Further research is needed to clarify whether there is underdiagnosis of lactotroph adenomas co-occurring with gonadotroph adenomas.