关于骨关节炎和疼痛的分子机制的当前综述。
关键词: ADAMTS-4 Anti-IL-1 BMP-7 Biochemical mediators COX Cartilage DRG E prostanoid receptor ECM EP ERK FGF-2 FGFR1-Ras Fn-f IGF-1 IL IL-1ra IL-1β IVD JNK LIF Lf LfcinB MAPKs MMP NFκB NSAIDS OA Osteoarthritic pain Osteoarthritis PG PGD2 PGE synthase PGE2 PGES PGF2Fa PGI2 PKCδ RA RNA ROS RSV SP TNF-α TNFR a disintergrin and metalloproteinase with thrombospondin motifs anti-interleukin 1 bone morphogenetic protein 7 bovine lactoferrin c-Jun N-terminal kinase cAMP cyclic adenosine monophosphate cyclooxygenase dorsal root ganglion extracellular matrix extracellular signal-regulated kinase fibroblast growth factor 2 fibroblast growth factor receptor 1-Ras fibronectin fragment iNOS inducible nitric oxide synthase insulin-like growth factor 1 interleukin interleukin-1 beta interleukin-1 receptor antagonist intervertebral disk lactoferrin leukemia inducing factor mPGES-1 mRNA matrix metalloproteinase messenger ribonucleic acid microsomal prostaglandin E synthase-1 mitogen-activated protein kinase nonsteroidal anti-inflammatory drugs nuclear factor kappa-light-chain-enhancer of activated B cells osteoarthritis prostaglandin D2 prostaglandin E2 prostaglandin I2 prostaglandin fibroblast growth factor alpha protein kinase C alpha proteoglycan reactive oxygen species resveratrol rheumatoid arthritis ribonucleic acid substance P tumor necrosis factor alpha tumor necrosis factor receptor
Mesh : Humans Osteoarthritis / genetics Pain / genetics
来 源:
DOI:10.1016/j.gene.2013.05.069
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