背景:下腰痛影响75%-85%的人在他们的生活中。用钠(23Na)MRI检测生化变化有可能实现更早,更准确的诊断。
目的:为了测量离体椎间盘(IVD)中的23Na弛豫时间和表观组织钠浓度(aTSC),并研究aTSC与组织学汤普森分级之间的关系。
方法:离体。
方法:来自11名人体供体(4名女性,7男,平均年龄86±8岁)。
■3T;密度适应的3D径向序列(DA-3D-RAD)。
结果:IVD23Na纵向(T1),对于每个脊柱样本(11个IVD),计算了短和长横向(T2s*和T2l*)松弛时间以及短横向松弛(ps)的比例。此外,计算所有IVD的aTSC。通过组织学Thompson分级评估IVD的降解。
方法:在aTSC和Thompson等级之间进行KendallTau相关性(τ)检验。显著性水平设定为P<0.05。
结果:11个IVD子集的平均23Na弛豫参数为T1=9.8±1.3毫秒,T2s*=0.7±0.1毫秒,T2l*=7.3±1.1毫秒,和ps=32.7±4.0%。总共检查了30个IVD,其中3名汤普森1级,4名2级,5名3级,5名4级,13名5级5级。aTSC随着降解的增加而降低,Thompson1级为274.6±18.9mM,Thompson5级为190.5±29.5mM。整个IVDaTSC与Thompson等级之间的相关性显着并且呈强烈负相关(τ=-0.56)。
结论:本研究显示aTSC与退行性IVD变化之间存在显著相关性。因此,TSC有可能是有用的作为退行性脊柱变化的指标。
方法:2技术效果:第一阶段。
BACKGROUND: Lower back pain affects 75%-85% of people at some point in their lives. The detection of biochemical changes with sodium (23Na) MRI has potential to enable an earlier and more accurate diagnosis.
OBJECTIVE: To measure 23Na relaxation times and apparent tissue sodium concentration (aTSC) in ex-vivo intervertebral discs (IVDs), and to investigate the relationship between aTSC and histological Thompson grade.
METHODS: Ex-vivo.
METHODS: Thirty IVDs from the lumbar spines of 11 human body donors (4 female, 7 male, mean age 86 ± 8 years).
UNASSIGNED: 3 T; density-adapted 3D radial sequence (DA-3D-RAD).
RESULTS: IVD 23Na longitudinal (T1), short and long transverse (T2s* and T2l*) relaxation times and the proportion of the short transverse relaxation (ps) were calculated for one
IVD per spine sample (11 IVDs). Furthermore, aTSCs were calculated for all IVDs. The degradation of the IVDs was assessed via histological Thompson grading.
METHODS: A Kendall Tau correlation (τ) test was performed between the aTSCs and the Thompson grades. The significance level was set to P < 0.05.
RESULTS: Mean 23Na relaxation parameters of a subset of 11 IVDs were T1 = 9.8 ± 1.3 msec, T2s* = 0.7 ± 0.1 msec, T2l* = 7.3 ± 1.1 msec, and ps = 32.7 ± 4.0%. A total of 30 IVDs were examined, of which 3 had Thompson grade 1, 4 had grade 2, 5 had grade 3, 5 had grade 4, and 13 had grade 5. The aTSC decreased with increasing degradation, being 274.6 ± 18.9 mM for Thompson grade 1 and 190.5 ± 29.5 mM for Thompson grade 5. The correlation between whole
IVD aTSC and Thompson grade was significant and strongly negative (τ = -0.56).
CONCLUSIONS: This study showed a significant correlation between aTSC and degenerative
IVD changes. Consequently, aTSC has potential to be useful as an indicator of degenerative spinal changes.
METHODS: 2 TECHNICAL EFFICACY: Stage 1.