背景:生物标记是生化指标,可以识别系统结构或功能的变化,器官,或细胞,可用于监测广泛的生物过程,包括癌症.白细胞介素-1受体拮抗剂(IL1RA)是一种重要的炎症抑制基因和肿瘤生物标志物。这项研究的目的是研究IL1RA的表达,其可能的致癌活性,及其在口腔鳞状细胞癌(OSCC)中的诊断靶点。
结果:我们发现,与正常上皮组织相比,IL1RA在OSCC肿瘤组织中的表达水平较低,并且从上皮增生到异型增生到原位癌和浸润性OSCC的表达逐渐下降。低IL1RA表达不仅与低生存率相关,而且与各种临床病理标志物如浸润增加相关。复发,和死亡。在过表达IL1RA的OSCC细胞中进行细胞表型研究后,我们发现恢复IL1RA表达降低了OSCC细胞增殖,迁移,和增加细胞凋亡。
结论:总之,我们的研究强调了OSCC细胞中低表达IL1RA可能参与促进侵袭和转移以及抑制细胞凋亡,以及以IL1RA为重点的监测在OSCC早期发现和治疗中的疗效。
Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, or cells and can be used to monitor a wide range of biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene and tumor biomarker. The goal of this study was to investigate the expression of IL1RA, its probable carcinogenic activity, and its diagnostic targets in oral squamous cell carcinoma (OSCC).
We discovered that IL1RA was expressed at a low level in OSCC tumor tissues compared to normal epithelial tissues and that the expression declined gradually from epithelial hyperplasia through dysplasia to carcinoma in situ and invasive OSCC. Low IL1RA expression was associated not only with poor survival but also with various clinicopathological markers such as increased infiltration, recurrence, and fatalities. Following cellular phenotyping investigations in OSCC cells overexpressing IL1RA, we discovered that recovering IL1RA expression decreased OSCC cell proliferation, migration, and increased apoptosis.
In summary, our investigation highlighted the possible involvement of low-expression IL1RA in OSCC cells in promoting invasive as well as metastatic and inhibiting apoptosis, as well as the efficacy of IL1RA-focused monitoring in the early detection and treatment of OSCC.