这项研究的目的是评估膳食补充剂是否包含佛手香和朝鲜蓟提取物的营养混合物-两者均在其特征多酚部分中标准化-可以积极影响血清脂质浓度和胰岛素敏感性。高敏C反应蛋白(hs-CRP),90例胆固醇水平欠佳的健康个体的非酒精性脂肪性肝病(NAFLD)指标。参与者被随机分配到积极治疗或安慰剂的药丸治疗。6周后,积极治疗组的甘油三酯(TG)水平显着改善,载脂蛋白B-100(ApoB-100),和载脂蛋白AI(ApoAI)与基线。总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),非高密度脂蛋白胆固醇(Non-HDL-C),与基线和安慰剂组相比,活性治疗组的hs-CRP也显著降低.在12周的随访中,分配到合并营养品的个人在TC方面有了显著改善,LDL-C,非HDL-C,TG,ApoB-100,ApoAI,葡萄糖,丙氨酸转氨酶(ALT),γ-谷氨酰转移酶(gGT),hs-CRP,NAFLD的几个指标,与基线相比,肱脉搏容积(PV)。TC的改进,LDL-C,非HDL-C,TG,脂肪肝指数(FLI),hs-CRP,与安慰剂相比,还检测到内皮反应性(全部p<0.05)。总的来说,这些研究结果支持使用含有佛手和朝鲜蓟干提取物的测试膳食补充剂作为预防和管理广泛的心脏代谢紊乱的安全和有效的方法。
The aim of this study was to assess whether dietary supplementation with a nutraceutical blend comprising extracts of bergamot and artichoke-both standardized in their characteristic polyphenolic fractions-could positively affect serum lipid concentration and insulin sensitivity, high-sensitivity C-reactive protein (hs-CRP), and indexes of non-alcoholic fatty liver disease (NAFLD) in 90 healthy individuals with suboptimal cholesterol levels. Participants were randomly allocated to treatment with a pill of either active treatment or placebo. After 6 weeks, the active-treated group experienced significant improvements in levels of triglycerides (TG), apolipoprotein B-100 (Apo B-100), and apolipoprotein AI (Apo AI) versus baseline. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (Non-HDL-C), and hs-CRP also significantly decreased in the active-treated group compared to both baseline and placebo. At the 12-week follow-up, individuals allocated to the combined nutraceutical experienced a significant improvement in TC, LDL-C, Non-HDL-C, TG, Apo B-100, Apo AI, glucose, alanine transaminase (ALT), gamma-glutamyl transferase (gGT), hs-CRP, several indexes of NAFLD, and brachial pulse volume (PV) in comparison with baseline. Improvements in TC, LDL-C, Non-HDL-C, TG, fatty liver index (FLI), hs-CRP, and endothelial reactivity were also detected compared to placebo (p < 0.05 for all). Overall, these findings support the use of the tested dietary supplement containing dry extracts of bergamot and artichoke as a safe and effective approach for the prevention and management of a broad spectrum of cardiometabolic disorders.