%0 Journal Article
%T AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation.
%A Cicek B
%A Hacimuftuoglu A
%A Yeni Y
%A Kuzucu M
%A Genc S
%A Cetin A
%A Yavuz E
%A Danısman B
%A Levent A
%A Ozdokur KV
%A Kantarcı M
%A Docea AO
%A Siokas V
%A Tsarouhas K
%A Coleman MD
%A Tsatsakis A
%A Taghizadehghalehjoughi A
%J Environ Toxicol Pharmacol
%V 107
%N 0
%D 2024 Apr 15
%M 38493879
%F 5.785
%R 10.1016/j.etap.2024.104417
%X The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.