{Reference Type}: Journal Article
{Title}: AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation.
{Author}: Cicek B;Hacimuftuoglu A;Yeni Y;Kuzucu M;Genc S;Cetin A;Yavuz E;Danısman B;Levent A;Ozdokur KV;Kantarcı M;Docea AO;Siokas V;Tsarouhas K;Coleman MD;Tsatsakis A;Taghizadehghalehjoughi A;
{Journal}: Environ Toxicol Pharmacol
{Volume}: 107
{Issue}: 0
{Year}: 2024 Apr 15
{Factor}: 5.785
{DOI}: 10.1016/j.etap.2024.104417
{Abstract}: The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.