背景2019年冠状病毒病(COVID-19)大流行已在很大程度上由疫苗控制。然而,在接种疫苗的个体中观察到COVID-19感染显著增加。疫苗接种所赋予的保护仍然是正在进行的讨论和研究的主题。我们的研究旨在评估疫苗接种状况对人口统计学的影响,临床表现,以及入院并随后住院接受进一步评估和治疗的患者的实验室特征。方法我们检查了住院的COVID-19患者的人口统计学,免疫接种状况,临床和实验室检查结果,以及在三角洲变异流行的七个月期间的结果。根据疫苗接种状态将患者分为三组:未接种疫苗(n=1,321,53.3%),部分接种疫苗(n=214,8.6%),和完全接种(n=944,38.1%)。对这些患者的数据进行了组间比较。结果纳入2479例聚合酶链反应(PCR)确诊的住院COVID-19患者。未接种疫苗的中位年龄(范围),部分接种疫苗,因COVID-19感染而需要住院治疗的完全接种疫苗的患者为51(18-98),61(21-91)71(23-99)分别(p<0.001)。白细胞计数,中性粒细胞,单核细胞,血小板计数,和炎症标志物,如红细胞沉降率,C反应蛋白,降钙素原,和IL-6,以及纤维蛋白原和肌钙蛋白T水平,观察到与未接种疫苗和部分接种疫苗的患者相比,完全接种疫苗的患者更高。临床随访显示,重症监护病房(ICU)的入院率,住院时间,与其他组相比,完全接种疫苗组的死亡率也较高。结论我们的研究结果表明,全面接种疫苗可以显着降低具有平均风险的年轻个体的住院率。然而,有高危因素的患者,如高龄和多种合并症,表现出更高的住院率,对重症监护的需求增加,住院时间更长,炎症标志物升高,即使完全接种疫苗,死亡率也更高。对于老年患者来说,在急诊就诊期间接受全面评估并获得早期治疗以降低潜在的发病率和死亡率至关重要。
Background The coronavirus disease 2019 (COVID-19) pandemic has been largely controlled by vaccines. However, a notable increase in COVID-19 infections has been observed among vaccinated individuals. The protection conferred by vaccination remains a topic of ongoing discussion and research. Our study aims to assess the impact of vaccination status on the demographics, clinical presentations, and laboratory characteristics of patients who were admitted to the hospital and subsequently hospitalized for further evaluation and treatment. Methods We examined hospitalized COVID-19 patients in terms of demographics, immunization status, clinical and laboratory findings, and outcomes over a seven-month period during which the delta variant was prevalent. Patients were categorized into three groups based on their vaccination status: unvaccinated (n=1,321, 53.3%), partially vaccinated (n=214, 8.6%), and fully vaccinated (n=944, 38.1%). Data from these patients were compared across groups. Results The study included 2,479 polymerase chain reaction (PCR)-confirmed hospitalized COVID-19 patients. The median ages (range) for the unvaccinated, partially vaccinated, and fully vaccinated patients who required hospitalization due to COVID-19 infection were 51 (18-98), 61 (21-91), and 71 (23-99), respectively (p<0.001). White blood cell count, neutrophils, monocytes, platelet count, and inflammatory markers such as erythrocyte sedimentation rate, C-reactive protein, procalcitonin, and IL-6, as well as fibrinogen and troponin T levels, were observed to be higher in the fully vaccinated patients compared to the unvaccinated and partially vaccinated patients. Clinical follow-ups showed that the intensive care unit (ICU) admission rates, length of hospital stay, and mortality rates were also higher in the fully vaccinated group compared to the other groups. Conclusion Our findings indicate that full vaccination significantly reduces hospitalization rates in younger individuals with average risk. However, patients with high-risk factors, such as advanced age and multiple comorbidities, exhibited higher hospitalization rates, increased need for intensive care, longer hospital stays, elevated inflammatory markers, and higher mortality even when fully vaccinated. It is crucial for elderly patients to receive thorough evaluations during emergency visits and to be provided with early treatment to reduce potential morbidity and mortality.