PDF(Pubmed)
Abstract：
BACKGROUND: The vaccination status of post-stroke patients, who are at high risk of severe outcomes from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a significant concern, yet it remains unclear. We aimed to explore the vaccination status, factors associated with vaccine hesitancy, and adverse effects after vaccination among post-stroke patients.
METHODS: This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.
RESULTS: Of the total 710 post-stroke patients included in the study, 430 (60.6%) had completed the recommended full-3 dose SARS-CoV-2 vaccination, with 176 (24.8%) remaining unvaccinated. The most common reasons for vaccine hesitancy were concerns about vaccine side effects (41.5%) and impaired mobility (33.9%). Logistic regression identified advanced age (aOR = 1.97, 95%CI: 1.36-2.85, P = 0.001), lower Barthel Index score (aOR = 0.88, 95%CI: 0.82-0.93, P = 0.018), higher Modified Rankin Scale score (aOR = 1.85, 95%CI: 1.32-2.56, P = 0.004), and poorer usual activity level of EuroQol 5-Dimension (aOR = 2.82, 95%CI: 1.51-5.28, P = 0.001) as independent risk factors for vaccine hesitancy. Approximately 14.8% reported minor adverse reactions, mainly pain at the injection site.
CONCLUSIONS: We found that post-stroke patients have insufficient SARS-CoV-2 vaccination rates, with key risk factors for vaccine hesitancy including concerns about side effects, advanced age, and functional impairments. No severe adverse reactions were observed among the vaccinated population.
METHODS: This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.
RESULTS: Of the total 710 post-stroke patients included in the study, 430 (60.6%) had completed the recommended full-3 dose SARS-CoV-2 vaccination, with 176 (24.8%) remaining unvaccinated. The most common reasons for vaccine hesitancy were concerns about vaccine side effects (41.5%) and impaired mobility (33.9%). Logistic regression identified advanced age (aOR = 1.97, 95%CI: 1.36-2.85, P = 0.001), lower Barthel Index score (aOR = 0.88, 95%CI: 0.82-0.93, P = 0.018), higher Modified Rankin Scale score (aOR = 1.85, 95%CI: 1.32-2.56, P = 0.004), and poorer usual activity level of EuroQol 5-Dimension (aOR = 2.82, 95%CI: 1.51-5.28, P = 0.001) as independent risk factors for vaccine hesitancy. Approximately 14.8% reported minor adverse reactions, mainly pain at the injection site.
CONCLUSIONS: We found that post-stroke patients have insufficient SARS-CoV-2 vaccination rates, with key risk factors for vaccine hesitancy including concerns about side effects, advanced age, and functional impairments. No severe adverse reactions were observed among the vaccinated population.
摘要：
背景：卒中后患者的疫苗接种状况，谁是严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）的严重结局的高风险，是一个重要的问题，但仍不清楚。我们旨在探索疫苗接种状况，与疫苗犹豫相关的因素，以及卒中后患者接种疫苗后的不良反应。
方法：这项多中心观察性研究纳入了来自六家中国医院的住院卒中后患者（2020年10月1日-2021年3月31日），检查疫苗摄取和自我报告的疫苗犹豫的原因，利用Logistic回归调查疫苗犹豫的危险因素，并记录疫苗接种后的任何不良反应。
结果：在纳入研究的总共710名中风后患者中，430人（60.6%）完成了推荐的全3剂SARS-CoV-2疫苗接种，176人（24.8%）未接种疫苗。疫苗犹豫的最常见原因是对疫苗副作用(41.5%)和流动性受损(33.9%)的担忧。Logistic回归确定高龄（aOR=1.97，95CI：1.36-2.85，P=0.001），较低的Barthel指数得分（aOR=0.88，95CI：0.82-0.93，P=0.018），改良Rankin量表评分较高（aOR=1.85，95CI：1.32-2.56，P=0.004），和EuroQol5维的常规活动水平较差（aOR=2.82，95CI：1.51-5.28，P=0.001）是疫苗犹豫的独立危险因素。大约14.8%报告了轻微的不良反应，主要是注射部位疼痛。
结论：我们发现卒中后患者SARS-CoV-2疫苗接种率不足，疫苗犹豫的关键风险因素包括对副作用的担忧，高龄,和功能障碍。在接种疫苗的人群中没有观察到严重的不良反应。
方法：这项多中心观察性研究纳入了来自六家中国医院的住院卒中后患者（2020年10月1日-2021年3月31日），检查疫苗摄取和自我报告的疫苗犹豫的原因，利用Logistic回归调查疫苗犹豫的危险因素，并记录疫苗接种后的任何不良反应。
结果：在纳入研究的总共710名中风后患者中，430人（60.6%）完成了推荐的全3剂SARS-CoV-2疫苗接种，176人（24.8%）未接种疫苗。疫苗犹豫的最常见原因是对疫苗副作用(41.5%)和流动性受损(33.9%)的担忧。Logistic回归确定高龄（aOR=1.97，95CI：1.36-2.85，P=0.001），较低的Barthel指数得分（aOR=0.88，95CI：0.82-0.93，P=0.018），改良Rankin量表评分较高（aOR=1.85，95CI：1.32-2.56，P=0.004），和EuroQol5维的常规活动水平较差（aOR=2.82，95CI：1.51-5.28，P=0.001）是疫苗犹豫的独立危险因素。大约14.8%报告了轻微的不良反应，主要是注射部位疼痛。
结论：我们发现卒中后患者SARS-CoV-2疫苗接种率不足，疫苗犹豫的关键风险因素包括对副作用的担忧，高龄,和功能障碍。在接种疫苗的人群中没有观察到严重的不良反应。
