METHODS: This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.
RESULTS: Of the total 710 post-stroke patients included in the study, 430 (60.6%) had completed the recommended full-3 dose SARS-CoV-2 vaccination, with 176 (24.8%) remaining unvaccinated. The most common reasons for vaccine hesitancy were concerns about vaccine side effects (41.5%) and impaired mobility (33.9%). Logistic regression identified advanced age (aOR = 1.97, 95%CI: 1.36-2.85, P = 0.001), lower Barthel Index score (aOR = 0.88, 95%CI: 0.82-0.93, P = 0.018), higher Modified Rankin Scale score (aOR = 1.85, 95%CI: 1.32-2.56, P = 0.004), and poorer usual activity level of EuroQol 5-Dimension (aOR = 2.82, 95%CI: 1.51-5.28, P = 0.001) as independent risk factors for vaccine hesitancy. Approximately 14.8% reported minor adverse reactions, mainly pain at the injection site.
CONCLUSIONS: We found that post-stroke patients have insufficient SARS-CoV-2 vaccination rates, with key risk factors for vaccine hesitancy including concerns about side effects, advanced age, and functional impairments. No severe adverse reactions were observed among the vaccinated population.
方法:这项多中心观察性研究纳入了来自六家中国医院的住院卒中后患者(2020年10月1日-2021年3月31日),检查疫苗摄取和自我报告的疫苗犹豫的原因,利用Logistic回归调查疫苗犹豫的危险因素,并记录疫苗接种后的任何不良反应。
结果:在纳入研究的总共710名中风后患者中,430人(60.6%)完成了推荐的全3剂SARS-CoV-2疫苗接种,176人(24.8%)未接种疫苗。疫苗犹豫的最常见原因是对疫苗副作用(41.5%)和流动性受损(33.9%)的担忧。Logistic回归确定高龄(aOR=1.97,95CI:1.36-2.85,P=0.001),较低的Barthel指数得分(aOR=0.88,95CI:0.82-0.93,P=0.018),改良Rankin量表评分较高(aOR=1.85,95CI:1.32-2.56,P=0.004),和EuroQol5维的常规活动水平较差(aOR=2.82,95CI:1.51-5.28,P=0.001)是疫苗犹豫的独立危险因素。大约14.8%报告了轻微的不良反应,主要是注射部位疼痛。
结论:我们发现卒中后患者SARS-CoV-2疫苗接种率不足,疫苗犹豫的关键风险因素包括对副作用的担忧,高龄,和功能障碍。在接种疫苗的人群中没有观察到严重的不良反应。