PDF(Pubmed)
Abstract：
The recent SARS-CoV-2 pandemic and the vaccination campaign posed a challenge to patients with autoimmune disease, such as multiple sclerosis (MS). We aimed for investigating whether psychological/sociodemographic/clinical characteristics of MS patients are associated with SARS-CoV-2 vaccination status and self-reported vaccination side effects (SEs). We have asked patients with MS about their willingness to receive recommended standard vaccinations pre-pandemically since June 2019. Between 10/2021 and 01/2022, we surveyed 193 of these MS patients about their current SARS-CoV-2 vaccination status, their perception of vaccination-related SEs, and reasons for and against SARS-CoV-2 vaccination. 75.6% of the patients declared their willingness to receive standard vaccinations before the pandemic. 84.5%, 78.2%, and 13.0% of the patients had received the first, second, and third SARS-CoV-2 vaccination, respectively, until the follow-up survey. The most common reason for not getting vaccinated against SARS-CoV-2 was concern about possible side effects (82.1%), followed by the belief that the vaccines had not been adequately tested (64.3%). Vaccination-related SEs were reported by 52.8% of the patients. Younger age, higher education, lower degree of disability, relapsing disease course, shorter disease duration, not receiving a disease-modifying therapy and higher anxiety and depression levels were associated with the occurrence of certain vaccination-related SEs. Concerns about novel vaccines are widespread among MS patients and necessitate targeted education of the patients, especially to those with more severe psychopathological symptoms (anxiety or depression) and those who are generally skeptical of vaccination.
摘要：
最近的SARS-CoV-2大流行和疫苗接种运动对自身免疫性疾病患者提出了挑战,如多发性硬化症（MS）。我们旨在调查MS患者的心理/社会人口统计学/临床特征是否与SARS-CoV-2疫苗接种状态和自我报告的疫苗接种副作用（SE）相关。我们已询问MS患者自2019年6月以来是否愿意在大流行前接受推荐的标准疫苗接种。在2021年10月至2022年1月之间，我们调查了193名MS患者目前的SARS-CoV-2疫苗接种状况，他们对疫苗接种相关SE的看法，以及支持和反对SARS-CoV-2疫苗接种的原因。75.6％的患者表示愿意在大流行之前接受标准疫苗接种。84.5%,78.2%,13.0%的患者接受了第一次，第二,和第三次SARS-CoV-2疫苗接种，分别,直到后续调查。未接种SARS-CoV-2疫苗的最常见原因是担心可能的副作用（82.1％），其次是认为疫苗没有经过充分测试(64.3%).52.8%的患者报告了与疫苗接种相关的SE。年龄更小,高等教育,残疾程度较低，复发性疾病的过程，疾病持续时间较短，未接受疾病改善治疗以及较高的焦虑和抑郁水平与某些疫苗接种相关的SE的发生相关.对新型疫苗的担忧在MS患者中普遍存在，因此有必要对患者进行有针对性的教育。特别是那些有更严重的精神病理症状（焦虑或抑郁）和那些通常对疫苗接种持怀疑态度的人。
