背景:这项纵向研究评估了接受调强放疗(IMRT)治疗的头颈部肿瘤患者唾液蛋白组成与口腔黏膜炎(OM)临床发作/严重程度之间的关系。
方法:唾液样本/临床数据来自40例头颈部癌症患者,这些患者在IMRT前(T0)和IMRT后(T1=6m,T2=12米)(伦理批准/同意)。唾液流速,总蛋白质浓度,从唾液样本中确定分泌率,并与治疗前的值进行比较。OM被评估,总/特异性唾液蛋白,包括黏蛋白5B和7,IgA,胱抑素S,白蛋白,和α-淀粉酶,被量化了。
结果:95%的患者在IMRT期间经历了OM,有33个科目达到2和3级。在T1时,唾液流速显着降低,总蛋白分泌率,与基线相比,α-淀粉酶和胱抑素-S。值得注意的是,IMRT在任何时间点都没有显着改变粘蛋白5B和7或IgA分泌率。在T1时,所有分析的蛋白质都与OM结果相关。此外,T0时的IgA浓度与IMRT期间OM的严重程度之间存在显着负相关。
结论:这项研究揭示了接受IMRT的头颈部癌患者中几种唾液蛋白与OM之间的显著关联。需要进一步的纵向研究来证实这些结果。
结论:该研究有助于了解某些唾液蛋白与OM的关系。这可能是识别潜在唾液标志物的第一步,这些标志物可以为个性化医疗方法提供观点,以改善他们的生活质量(QoL)。
目的:头颈癌患者唾液蛋白与OM的发生和严重程度之间有什么关系?
目的:评估接受调强放疗的头颈癌患者唾液蛋白成分与口腔黏膜炎(OM)的临床发作/严重程度之间的关系。
目的:HNC患者唾液蛋白与OM的发病/严重程度无相关性。
BACKGROUND: This longitudinal study assessed the association between salivary protein composition and the clinical onset/severity of oral mucositis (OM) in patients with head and neck tumours treated with intensity-modulated-radiotherapy (IMRT).
METHODS: Saliva samples/clinical data were obtained from 40 head and neck cancer patients treated at Guy\'s Hospital before -IMRT(T0) and after-IMRT (T1 = 6 m, T2 = 12 m) (ethics approval/consent). Salivary flow rate, total protein concentration, and secretion rate were determined from saliva samples and compared with pre-treatment values. OM was assessed, total/specific salivary proteins, including mucin 5B and 7, IgA, cystatin-S, albumin, and α-amylase, were quantified.
RESULTS: 95% patients experienced OM during IMRT, with 33 subjects reaching grade 2&3. At T1, there was a significant reduction in salivary flow rate, total protein secretion rate, α-amylase and cystatin-S compared to baseline. Remarkably IMRT did not significantly alter mucin 5B and 7, or the IgA secretion rate at any time point. At T1, all the analyzed proteins were associated with the OM outcomes. In addition, there was a significant inverse correlation between IgA concentration at T0 and the severity of OM during IMRT.
CONCLUSIONS: This study revealed significant associations between several salivary proteins and OM in patients with head and neck cancer undergoing IMRT. Further longitudinal studies are needed to confirm these results.
CONCLUSIONS: The study contributes to the understanding of certain salivary proteins association with OM. This could be the first step towards identifying potential salivary markers that could offer perspectives for personalized medicine approaches to improve their quality of life (QoL).
OBJECTIVE: What is the association between salivary proteins and the occurrence and severity of OM in head and neck cancer patients?
OBJECTIVE: To assess the association between salivary protein composition with the clinical onset/severity of oral mucositis (OM) in head and neck cancer patients treated with intensity modulated radiotherapy.
OBJECTIVE: There is no association between salivary proteins and onset/severity of OM in HNC patients.