目的:本系统综述和荟萃分析旨在评估唾液蛋白多态性与牙周疾病(PD)风险之间的关联。
方法:这篇综述纳入了横截面,病例控制,回顾性/前瞻性队列,本综述包括评估唾液蛋白多态性对PD发生风险影响的随机对照试验。
方法:在电子数据库中进行了全面的文献检索,即PubMed,Scopus,Embase,和WebofScience,对出版语言和年份没有任何限制。
方法:共确定了168项研究,其中19人有资格入选。纳入研究的偏倚风险(RoB)评估在方法学层面进行。
结果:共纳入16项研究。发现编码TNF-α的基因的多态性对牙龈炎具有保护作用,而编码IL-1α和IL-1β的那些与牙龈炎的发展有关。在研究的42种蛋白质中,各种基因多态性被确定为牙周炎的保护或危险因素。保护性基因包括CFH,DNMT1、OPRM1和TLR9。相反,某些唾液蛋白质基因(例如,CRP,ERN1,FAM5C,IDH2,LTA,TET2,MPA,NLRP3、TLR4)与牙周炎风险有关。值得注意的是,IL6、MMP9和MUC7基因与PD无相关性,而MMP13与早期植入物丢失有关。总的来说,荟萃分析发现,唾液蛋白多态性与PD风险之间存在统计学显著关联.
结论:唾液蛋白多态性显著影响PD,揭示保护性和风险相关的基因型。尽管有局限性,研究结果表明治疗目标,强调复杂的遗传学-牙周健康相互作用。
结论:本研究揭示了唾液蛋白多态性是PD的关键因素。包括CFH和TLR9的保护性基因以及包括CRP和TLR4的风险相关基因表明了PD易感性的遗传基础。
The present systematic
review and meta-analysis aimed to assess the association between salivary protein polymorphisms and the risk of periodontal diseases (PD).
The
review incorporated cross-sectional, case-control, retrospective/prospective cohort, and randomized controlled trials assessing the influence of salivary protein polymorphisms on the risk of PD development were included in this
review.
A thorough literature search was conducted across electronic databases, namely PubMed, Scopus, Embase, and Web of Science, without any restrictions on publication language and year.
A total of 168 studies were identified, of which 19 were eligible for inclusion. The risk of bias (RoB) assessment of the included studies was conducted at the methodological level.
A total of 16 studies were included. Polymorphism in the gene encoding TNF-α was found to be protective against gingivitis, while those encoding IL-1α and IL-1β were associated with developing gingivitis. Of the 42 proteins investigated, various gene polymorphisms were identified as protective or risk factors for periodontitis. Protective genes include CFH, DNMT1, OPRM1, and TLR9. Conversely, certain salivary protein genes (e.g., CRP, ERN1, FAM5C, IDH2, LTA, TET2, MPA, NLRP3, TLR4) were associated with periodontitis risk. Notably, IL6, MMP9, and MUC7 genes showed no association with PD, while MMP13 was linked to early implant loss. Overall, the meta-analysis found a statistically significant association between salivary proteins\' polymorphisms and risk of PD.
Salivary protein polymorphisms significantly influence PD, revealing protective and risk-associated genotypes. Despite limitations, findings suggest therapeutic targets, emphasizing the complex genetics-periodontal health interplay.
This study unveils salivary protein polymorphisms as pivotal factors in PD. Protective genes including CFH and TLR9, and risk-associated genes including CRP and TLR4, indicate a genetic basis for PD susceptibility.