目的:孕妇有严重SARS-CoV-2感染的风险,可能导致产科和新生儿并发症。针对SARS-CoV-2的抗体的胎盘转移可能对新生儿COVID-19具有保护作用,但这仍有待研究。我们旨在确定未接种疫苗的孕妇人群中SARS-CoV-2抗体的血清阳性率,并确定这些抗体的胎盘转移。
方法:共有1197名未接种疫苗的妇女,其研究前SARS-CoV-2感染状况大多未知,在大流行的第一年,在交付时测试了SARS-CoV-2刺突蛋白IgG抗体。如果母亲是血清阳性,则收集脐带样品并评估血清阳性。产妇特征,我们从病历中提取了妊娠和新生儿结局以及SARS-CoV-2感染数据.
结果:在258名女性中检测到特异性IgG(21.6%)。在81.3%的病例中观察到明显的胎盘转移到新生儿。在第二和第三三个月,母亲感染了这种疾病,症状越严重,IgG经胎盘转移至新生儿的可能性越大。
结论:在大流行的第一年,大约五分之一的女性在分娩时检测到抗SARS-CoV-2刺突蛋白IgG抗体,这些抗体明显转移到胎儿。这项研究提供了进一步的证据,以更好地了解SARS-CoV-2IgG抗体从母亲到新生儿的胎盘转移的动力学,这对于改进疫苗接种策略是必要的。
OBJECTIVE: Pregnant women are at risk of severe SARS-CoV-2 infection, potentially leading to obstetric and neonatal complications. Placental transfer of antibodies directed to SARS-CoV-2 may be protective against neonatal COVID-19, but this remains to be studied. We aimed to determine the seroprevalence of SARS-CoV-2 antibodies in a population of unvaccinated pregnant women and to determine the placental transfer of these antibodies.
METHODS: A total of 1197 unvaccinated women with mostly unknown pre-study SARS-CoV-2 infection status, were tested at delivery for SARS-CoV-2 spike protein IgG antibodies during the first year of the pandemic. Umbilical cord samples were collected and assessed for seropositivity if the mother was seropositive. Maternal characteristics, pregnancy and neonatal outcomes and data on SARS-CoV-2 infection were extracted from medical records.
RESULTS: Specific IgG were detected in 258 women (21.6%). A significant placental transfer to the newborn was observed in 81.3% of cases. The earlier in the 2nd and 3rd trimesters that the mother had contracted the disease and the more symptomatic she was, the greater the likelihood of transplacental transfer of IgG to her newborn.
CONCLUSIONS: Approximately one in five women had detectable anti-SARS-CoV-2 spike protein IgG antibodies at delivery during the first year of the pandemic, and these antibodies were significantly transferred to their fetuses. This research provides further evidence to better understand the dynamics of the placental transfer of SARS-CoV-2 IgG antibodies from mothers to their newborns, which is necessary to improve vaccination strategies.