PDF(Pubmed)
Abstract：
Endocytosis represents a category of regulated active transport mechanisms. These encompass clathrin-dependent and -independent mechanisms, as well as fluid phase micropinocytosis and macropinocytosis, each demonstrating varying degrees of specificity and capacity. Collectively, these mechanisms facilitate the internalization of cargo into cellular vesicles. Pregnancy is one such physiological state during which endocytosis may play critical roles. A successful pregnancy necessitates ongoing communication between maternal and fetal cells at the maternal-fetal interface to ensure immunologic tolerance for the semi-allogenic fetus whilst providing adequate protection against infection from pathogens, such as viruses and bacteria. It also requires transport of nutrients across the maternal-fetal interface, but restriction of potentially harmful chemicals and drugs to allow fetal development. In this context, trogocytosis, a specific form of endocytosis, plays a crucial role in immunological tolerance and infection prevention. Endocytosis is also thought to play a significant role in nutrient and toxin handling at the maternal-fetal interface, though its mechanisms remain less understood. A comprehensive understanding of endocytosis and its mechanisms not only enhances our knowledge of maternal-fetal interactions but is also essential for identifying the pathogenesis of pregnancy pathologies and providing new avenues for therapeutic intervention.
摘要：
胞吞作用代表一类受调节的主动转运机制。这些包括网格蛋白依赖和独立的机制，以及液相微胞饮作用和巨细胞作用，每个都表现出不同程度的特异性和能力。总的来说，这些机制促进货物内化进入细胞囊泡。妊娠是一种这样的生理状态,在该状态期间内吞作用可能起关键作用。成功的妊娠需要母体和胎儿细胞在母胎界面上持续的交流，以确保对半同种异体胎儿的免疫耐受，同时提供足够的保护，防止病原体感染。如病毒和细菌。它还需要通过母胎界面运输营养物质，但限制潜在有害的化学物质和药物，以允许胎儿发育。在这种情况下，红细胞增多症，一种特定形式的内吞作用，在免疫耐受和感染预防中起着至关重要的作用。胞吞作用也被认为在母胎界面的营养和毒素处理中起重要作用。虽然它的机制仍然不太了解。对内吞作用及其机制的全面了解不仅可以增强我们对母胎相互作用的认识，而且对于确定妊娠病理的发病机理并为治疗干预提供新的途径也是必不可少的。
