PDF(Pubmed)
Abstract：
UNASSIGNED: Normal pregnancy is a contradictory and complicated physiological process. Although the fetus carries the human leukocyte antigen (HLA) inherited from the paternal line, it does not cause maternal immune rejection. As the only exception to immunological principles, maternal-fetal immune tolerance has been a reproductive immunology focus. In early pregnancy, fetal extravillous trophoblast cells (EVTs) invade decidual tissues and come into direct contact with maternal decidual immune cells (DICs) and decidual stromal cells (DSCs) to establish a sophisticated maternal-fetal crosstalk. This study reviews previous research results and focuses on the establishment and maintenance mechanism of maternal-fetal tolerance based on maternal-fetal crosstalk. Insights into maternal-fetal tolerance will not only improve understanding of normal pregnancy but will also contribute to novel therapeutic strategies for recurrent spontaneous abortion, pre-eclampsia, and premature birth.
摘要：
■正常怀孕是一个矛盾而复杂的生理过程。尽管胎儿携带从父系遗传的人类白细胞抗原（HLA），它不会引起母体免疫排斥。作为免疫学原理的唯一例外，母胎免疫耐受一直是生殖免疫学研究的热点.在怀孕早期,胎儿绒毛外滋养层细胞（EVT）侵入蜕膜组织，并与母体蜕膜免疫细胞（DIC）和蜕膜基质细胞（DSC）直接接触，以建立复杂的母胎串扰。本研究回顾了前人的研究成果,重点探讨了基于母胎串扰的母胎耐受的建立和维持机制。对母胎耐受性的认识不仅可以提高对正常妊娠的认识，还可以为复发性自然流产提供新的治疗策略。先兆子痫,和早产。
