PDF(Pubmed)
Abstract：
The fetal development of organs and functions is vulnerable to perturbation by maternal inflammation which may increase susceptibility to disorders after birth. Because it is not well understood how the placenta and fetus respond to acute lung- inflammation, we characterize the response to maternal pulmonary lipopolysaccharide exposure across 24 h in maternal and fetal organs using multi-omics, imaging and integrative analyses. Unlike maternal organs, which mount strong inflammatory immune responses, the placenta upregulates immuno-modulatory genes, in particular the IL-6 signaling suppressor Socs3. Similarly, we observe no immune response in the fetal liver, which instead displays metabolic changes, including increases in lipids containing docosahexaenoic acid, crucial for fetal brain development. The maternal liver and plasma display similar metabolic alterations, potentially increasing bioavailability of docosahexaenoic acid for the mother and fetus. Thus, our integrated temporal analysis shows that systemic inflammation in the mother leads to a metabolic perturbation in the fetus.
摘要：
器官和功能的胎儿发育容易受到母体炎症的干扰，这可能会增加出生后对疾病的易感性。因为尚不清楚胎盘和胎儿对急性肺部炎症的反应，我们描述了在24小时内母体和胎儿器官中母体肺脂多糖暴露的反应，成像和综合分析。与母体器官不同，产生强烈的炎症免疫反应，胎盘上调免疫调节基因，特别是IL-6信号传导抑制子Sock3。同样，我们在胎儿肝脏中没有观察到免疫反应，而是显示新陈代谢的变化，包括含有二十二碳六烯酸的脂质增加，对胎儿大脑发育至关重要.母体肝脏和血浆显示相似的代谢改变，可能增加二十二碳六烯酸对母亲和胎儿的生物利用度。因此，我们的综合时间分析表明,母亲的全身性炎症会导致胎儿的代谢紊乱.
