PDF(Pubmed)
Abstract：
This study, conducted by searching keywords such as \"maternal lupus\", \"neonatal lupus\", and \"congenital heart block\" in databases including PubMed and Scopus, provides a detailed narrative review on fetal and neonatal lupus. Autoantibodies like anti-Ro/SSA and anti-La/SSB may cross the placenta and cause complications in neonates, such as congenital heart block (CHB). Management options involve hydroxychloroquine, which is able to counteract some of the adverse events, although the drug needs to be used carefully because of its impact on the QTc interval. Advanced pacing strategies for neonates with CHB, especially in severe forms like hydrops, are also assessed. This review emphasizes the need for interdisciplinary care by rheumatologists, obstetricians, and pediatricians in order to achieve the best maternal and neonatal health in lupus pregnancies. This multidisciplinary approach seeks to improve the outcomes and management of the disease, decreasing the burden on mothers and their infants.
摘要：
这项研究,通过搜索“母体狼疮”等关键词进行“新生儿狼疮”，以及PubMed和Scopus等数据库中的“先天性心脏传导阻滞”，提供了对胎儿和新生儿狼疮的详细叙述回顾。自身抗体如抗Ro/SSA和抗La/SSB可能穿过胎盘并引起新生儿并发症，如先天性心脏传导阻滞（CHB）。管理选择涉及羟氯喹，能够抵消一些不良事件，尽管由于该药物对QTc间期的影响，因此需要谨慎使用。新生儿CHB的高级起搏策略，尤其是在严重的形式，如积水，也进行了评估。这篇综述强调风湿病学家需要跨学科护理，产科医生,和儿科医生，以便在狼疮妊娠中实现最佳的孕产妇和新生儿健康。这种多学科方法旨在改善疾病的结果和管理，减轻母亲和婴儿的负担。
