PDF(Pubmed)
Abstract：
Mammalian reproduction relies on precise maternal-fetal communication, wherein immune modifications foster tolerance toward the semi-allogeneic embryo. Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as crucial mediators, transporting molecules like microRNAs securely. EVs influence various reproductive stages, from gamete maturation to implantation, and impact pathologies like pregnancy loss. In the embryo-maternal dialogue, EVs notably affect oviductal interactions, gene expression, and the embryo-endometrial interface, crucial for successful implantation. Key queries persist about EV uptake, cargo delivery, and the specific biomolecules driving communication. Their potential in diagnostics, therapeutics, and understanding environmental impacts on fertility signals an exciting future, reliant on collaborative efforts for transformative strides in reproductive health.
摘要：
哺乳动物的繁殖依赖于精确的母胎交流，其中免疫修饰促进对半同种异体胚胎的耐受性。细胞外囊泡（EV），包括外泌体和微泡，已经成为关键的调解人，安全地运输像microRNAs这样的分子。电动汽车影响不同的生殖阶段，从配子成熟到着床,并影响妊娠失败等病理。在胚胎-母体对话中，电动汽车显著影响输卵管相互作用，基因表达，和胚胎-子宫内膜界面，对于成功植入至关重要。关于电动汽车吸收的关键查询仍然存在，货物交付，和驱动交流的特定生物分子。他们在诊断方面的潜力，治疗学,了解环境对生育率的影响预示着一个令人兴奋的未来，依靠合作努力，实现生殖健康领域的变革。
