weather

天气
  • 文章类型: Journal Article
    许多呼吸道病毒及其相关疾病对气象因素敏感。对于SARS-CoV-2和COVID-19,关于这种敏感性的证据是不一致的。了解气象因素对SARS-CoV-2传播和COVID-19流行病学的影响有助于提高大流行准备。
    这篇综述旨在研究有关气象因素与SARS-CoV-2/COVID-19之间关系的最新证据。
    我们对2020年1月至2023年1月发表的关于温度之间关联的同行评审研究进行了全球范围审查太阳辐射,降水,湿度,湿度风速,和大气压和SARS-CoV-2/COVID-19。
    从9,156条初始记录中,我们纳入了474项相关研究.对SARS-CoV-2的实验研究提供了一致的证据,表明较高的温度和太阳辐射会对病毒的生存能力产生负面影响。关于COVID-19(流行病学)的研究大多是观察性的,提供的证据不太一致。几项研究考虑了气象因素或人口统计学或空气污染等其他变量之间的相互作用。所有出版物都没有从整体上包括所有决定因素。
    短期气象因素与SARS-CoV-2/COVID-19动力学之间的关联很复杂。环境和社会组成部分之间的相互作用需要进一步考虑。更综合的研究方法可以提供有价值的见解,以预测具有大流行潜力的呼吸道病毒的动态。
    UNASSIGNED: Many respiratory viruses and their associated diseases are sensitive to meteorological factors. For SARS-CoV-2 and COVID-19, evidence on this sensitivity is inconsistent. Understanding the influence of meteorological factors on SARS-CoV-2 transmission and COVID-19 epidemiology can help to improve pandemic preparedness.
    UNASSIGNED: This review aimed to examine the recent evidence about the relation between meteorological factors and SARS-CoV-2/COVID-19.
    UNASSIGNED: We conducted a global scoping review of peer-reviewed studies published from January 2020 up to January 2023 about the associations between temperature, solar radiation, precipitation, humidity, wind speed, and atmospheric pressure and SARS-CoV-2/COVID-19.
    UNASSIGNED: From 9,156 initial records, we included 474 relevant studies. Experimental studies on SARS-CoV-2 provided consistent evidence that higher temperatures and solar radiation negatively affect virus viability. Studies on COVID-19 (epidemiology) were mostly observational and provided less consistent evidence. Several studies considered interactions between meteorological factors or other variables such as demographics or air pollution. None of the publications included all determinants holistically.
    UNASSIGNED: The association between short-term meteorological factors and SARS-CoV-2/COVID-19 dynamics is complex. Interactions between environmental and social components need further consideration. A more integrated research approach can provide valuable insights to predict the dynamics of respiratory viruses with pandemic potential.
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  • 文章类型: Journal Article
    背景:天气和季节是体力活动的决定因素。因此,重要的是确保建筑环境的设计能够减轻天气和季节对行人的负面影响,以防止这些损失。本范围审查旨在确定为在特定天气条件或季节使用而开发的行人环境的建筑环境审计。其次,这项审查旨在调查在将相关天气缓解建筑环境特征纳入行人环境审计工具方面的差距。
    方法:遵循标准协议,在CINAHL中进行了系统搜索,Medline和WebofScience确定步行空间的建筑环境审计工具。之所以选择这些数据库,是因为它们众所周知,可以全面涵盖健康以及与健康相关的多学科研究出版物。研究进行了筛选,并且数据由两名独立的审阅者从选定的文档中提取(例如,包括心理测量属性和审计项目)。审核项目进行了筛选,包括天气缓解建筑环境功能,和工具测量温度的能力,降水,计算了对行人的季节性和可持续性影响。
    结果:搜索返回了2823个文档。经过筛选和全文审查,共27篇文章。没有发现专门开发用于特定天气条件或季节的工具。此外,在所有审查维度(热舒适度,降水,季节性,和可持续性项目)。覆盖较差的项目是:(1)热舒适相关(北极进入存在,材料,纹理,和建筑物的颜色,道路,人行道和家具,和绿色设计特征);(2)与降水相关的(排水存在,沟渠存在,危害,和除雪功能);(3)季节性功能(便利设施,行人规模照明,和冬季目的地和美学);和(4)可持续性特征(电动汽车充电站,可再生能源,汽车共享,和自行车共享设施)。
    结论:当前的建筑环境审计工具没有充分包括天气/季节缓解项目。这是一个限制,因为调查在行人空间中包含这些物品是否可以在不利的天气条件下促进身体活动是很重要的。因为气候变化导致极端天气事件增加,需要开发一种新的建筑环境审计工具,其中包括相关的天气缓解功能。
    BACKGROUND: Weather and season are determinants of physical activity. Therefore, it is important to ensure built environments are designed to mitigate negative impacts of weather and season on pedestrians to prevent these losses. This scoping review aims to identify built environment audits of pedestrian environments developed for use during a specific weather condition or season. Secondly, this review aims to investigate gaps in the inclusion of relevant weather mitigating built environment features in pedestrian environment audit tools.
    METHODS: Following a standard protocol, a systematic search was executed in CINAHL, Medline and Web of Science to identify built environment audit tools of pedestrian spaces. These databases were chosen since they are well-known to comprehensively cover health as well as multi-disciplinary research publications relevant to health. Studies were screened, and data were extracted from selected documents by two independent reviewers (e.g., psychometric properties and audit items included). Audit items were screened for the inclusion of weather mitigating built environment features, and the tool\'s capacity to measure temperature, precipitation, seasonal and sustainability impacts on pedestrians was calculated.
    RESULTS: The search returned 2823 documents. After screening and full text review, 27 articles were included. No tool was found that was developed specifically for use during a specific weather condition or season. Additionally, gaps in the inclusion of weather mitigating items were found for all review dimensions (thermal comfort, precipitation, seasonal, and sustainability items). Poorly covered items were: (1) thermal comfort related (arctic entry presence, materials, textures, and colours of buildings, roads, sidewalk and furniture, and green design features); (2) precipitation related (drain presence, ditch presence, hazards, and snow removal features); (3) seasonal features (amenities, pedestrian scale lighting, and winter destinations and aesthetics); and (4) sustainability features (electric vehicle charging stations, renewable energy, car share, and bike share facilities).
    CONCLUSIONS: Current built environment audit tools do not adequately include weather / season mitigating items. This is a limitation as it is important to investigate if the inclusion of these items in pedestrian spaces can promote physical activity during adverse weather conditions. Because climate change is causing increased extreme weather events, a need exists for the development of a new built environment audit tool that includes relevant weather mitigating features.
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  • 文章类型: Journal Article
    气候变化和空气污染导致的环境因素是包括痴呆症在内的许多慢性病的危险因素。尽管研究表明空气污染在认知状态方面的影响,对于气候变化与老年痴呆症患者的特定健康相关结局之间的关联知之甚少.作为回应,我们概述了一个范围审查方案,以系统地审查有关气候变化证据的已发表文献,包括温度和天气变化,与健康相关的生活质量,发病率,移动性,falls,卫生资源的利用,和老年痴呆症患者的死亡率。此范围审查将以Arksey和O\'Malley提出的框架为指导。电子搜索(Medline,Embase,PsycINFO,CINAHL,Scopus,WebofScience)使用相关的主题词和两个概念的同义词(患有痴呆症的老年人,天气/气候变化)。没有发布日期或其他限制将适用于搜索策略。为了理解非英语研究在文献中的影响,没有语言限制。符合条件的研究必须包括居住在社区中的患有痴呆症的老年人(65岁以上),并调查气候变化和/或天气对其健康相关生活质量的影响。发病率,移动性,falls,卫生资源的使用和死亡率。两名独立审稿人将筛选摘要,并选择全文审稿,执行这些审查,选择要保留的物品,并以标准化的方式从它们中提取数据。然后将合成和解释这些数据。OSF注册:DOI:10.17605/OSF。IO/YRFM8。
    Environmental factors resulting from climate change and air pollution are risk factors for many chronic conditions including dementia. Although research has shown the impacts of air pollution in terms of cognitive status, less is known about the association between climate change and specific health-related outcomes of older people living with dementia. In response, we outline a scoping review protocol to systematically review the published literature regarding the evidence of climate change, including temperature and weather variability, on health-related quality of life, morbidity, mobility, falls, the utilization of health resources, and mortality among older adults living with dementia. This scoping review will be guided by the framework proposed by Arksey and O\'Malley. Electronic search (Medline, Embase, PsycINFO, CINAHL, Scopus, Web of Science) using relevant subject headings and synonyms for two concepts (older people with dementia, weather/ climate change). No publication date or other restrictions will be applied to the search strategy. No language restriction will be applied in order to understand the impact of non-English studies in the literature. Eligible studies must include older adults (65+years) with dementia living in the community and investigate the impacts of climate change and/or weather on their health-related quality of life, morbidity, mobility, falls, use of health resources and mortality. Two independent reviewers will screen abstracts and select those for a full-text review, perform these reviews, select articles for retention, and extract data from them in a standardized manner. This data will then be synthesized and interpreted. OSF registration: DOI: 10.17605/OSF.IO/YRFM8.
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  • 文章类型: Journal Article
    目的:在这篇叙述性综述中,我们总结了2017年至2022年间发表的同行评审文献,这些文献评估了原发性头痛疾病的周围环境风险因素,影响全球一半以上的人口。原发性头痛疾病包括偏头痛,紧张型头痛(TTH),三叉神经和自主神经性头痛(TAC)。
    结果:我们通过PubMed或GoogleScholar确定了17篇符合入选标准的文章。七项研究(41%)依赖于美国人群的数据。其余研究在中国进行,台湾,德国,加纳,Japan,荷兰,韩国,和土耳其。空气污染是最经常评估的环境风险因素。大多数研究是横断面的,集中在全因或偏头痛;一项研究包括TTH,没有包括TAC。短期暴露于细颗粒物(PM2.5)并不总是与头痛终点相关,但在多项研究中,长期暴露于PM2.5与偏头痛患病率和严重程度相关.环境温度升高,天气的变化,油气井暴露,和较少的自然绿地,但不是噪音污染,也与头痛有关。没有研究考虑到水污染,金属暴露,超细颗粒物,或野火烟雾暴露。需要针对头痛和环境进行持续的研究。具有最大解释力的研究设计可能包括纵向研究,以捕捉头痛的偶发性和病例交叉分析。它通过设计控制时不变的个体级混杂因素。显然还需要进行研究,将合并症的精神疾病和社会经济地位视为环境对头痛影响的有力调节剂。
    In this narrative review, we summarize the peer-reviewed literature published between 2017 and 2022 that evaluated ambient environmental risk factors for primary headache disorders, which affect more than half of the population globally. Primary headache disorders include migraine, tension-type headache (TTH), and trigeminal and autonomic cephalalgias (TAC).
    We identified 17 articles that met the inclusion criteria via PubMed or Google Scholar. Seven studies (41%) relied on data from US populations. The remaining studies were conducted in China, Taiwan, Germany, Ghana, Japan, the Netherlands, South Korea, and Turkey. Air pollution was the most frequently assessed environmental risk factor. Most studies were cross-sectional and focused on all-cause or migraine headaches; one study included TTH, and none included TAC. Short-term exposure to fine particulate matter (PM2.5) was not consistently associated with headache endpoints, but long-term exposure to PM2.5 was associated with migraine headache prevalence and severity across multiple studies. Elevated ambient temperature, changes in weather, oil and gas well exposure, and less natural greenspace, but not noise pollution, were also associated with headache. No studies considered water pollution, metal exposure, ultrafine particulate matter, or wildfire smoke exposure. There is a need for ongoing research focused on headache and the environment. Study designs with the greatest explanatory power may include longitudinal studies that capture the episodic nature of headache and case-crossover analysis, which control for time-invariant individual-level confounders by design. There is also a clear need for research that considers comorbid psychiatric illness and socioeconomic position as powerful modifiers of the effect of the environment on headache.
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  • 文章类型: Systematic Review
    背景:先前的工作发现,气候变化引起的天气变异性被怀疑会增加肠道病原体的传播,包括弯曲杆菌,细菌性肠胃炎的主要原因。虽然已经记录了极端天气事件与腹泻疾病之间的关系,对弯曲杆菌感染的具体影响仍未充分研究.
    目的:综合同行评审的文献,探讨天气变化对人类弯曲杆菌感染的影响。
    方法:评论包括英语,同行评审的文章,截至2022年9月1日在PubMed上发布,Embase,GEOBASE,农业与环境科学数据库,和CABI全球健康探索前期天气事件对弯曲杆菌引起的人类肠道疾病的影响。(PROSPERO协议#351884)。我们提取了研究信息,包括数据源,方法,汇总措施,和效果大小。总结报告的证据的质量和权重,并评估每篇文章的偏倚。
    结果:筛选278篇文章后,47篇文章(34项研究,13份疫情报告)被纳入证据综合。前期天气事件包括降水(n=35),温度(n=30),相对湿度(n=7),阳光(n=6),厄尔尼诺和拉尼娜(n=3)。经过审查的研究表明,在特定条件下,降水和温度的增加与弯曲杆菌感染有关,相对湿度和日照呈负相关。评估动物手术效果的文章(n=15)发现,动物手术的存在和密度与感染显着相关。然而,大多数收录的文章都没有通过季节性来评估混杂情况,动物行动的存在,或描述风险的估计。
    结论:这篇综述探讨了关于天气事件对弯曲杆菌的影响的已知情况,并确定了以前报道不足的相对湿度和日照对弯曲杆菌感染的负相关性。未来的研究应该探索特定病原体的风险估计,可以用来影响公共卫生战略,改善来源归因和因果途径,并预测气候变化造成的疾病负担。
    BACKGROUND: Previous work has found climate change-induced weather variability is suspected to increase the transmission of enteric pathogens, including Campylobacter, a leading cause of bacterial gastroenteritis. While the relationship between extreme weather events and diarrheal diseases has been documented, the specific impact on Campylobacter infections remains underexplored.
    OBJECTIVE: To synthesize the peer-reviewed literature exploring the effect of weather variability on Campylobacter infections in humans.
    METHODS: The review included English language, peer-reviewed articles, published up to September 1, 2022 in PubMed, Embase, GEOBASE, Agriculture and Environmental Science Database, and CABI Global Health exploring the effect of an antecedent weather event on human enteric illness caused by Campylobacter (PROSPERO Protocol # 351884). We extracted study information including data sources, methods, summary measures, and effect sizes. Quality and weight of evidence reported was summarized and bias assessed for each article.
    RESULTS: After screening 278 articles, 47 articles (34 studies, 13 outbreak reports) were included in the evidence synthesis. Antecedent weather events included precipitation (n = 35), temperature (n = 30), relative humidity (n = 7), sunshine (n = 6), and El Niño and La Niña (n = 3). Reviewed studies demonstrated that increases in precipitation and temperature were correlated with Campylobacter infections under specific conditions, whereas low relative humidity and sunshine were negatively correlated. Articles estimating the effect of animal operations (n = 15) found presence and density of animal operations were significantly associated with infections. However, most of the included articles did not assess confounding by seasonality, presence of animal operations, or describe estimates of risk.
    CONCLUSIONS: This review explores what is known about the influence of weather events on Campylobacter and identifies previously underreported negative associations between low relative humidity and sunshine on Campylobacter infections. Future research should explore pathogen-specific estimates of risk, which can be used to influence public health strategies, improve source attribution and causal pathways, and project disease burden due to climate change.
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  • 文章类型: Journal Article
    城市非点源污染对地表水污染的贡献逐渐增大,分析城市NPS污染的来源对准确控制地表水污染具有重要意义。对2000年至2021年的相关研究文献进行文献计量分析,发现城市NPS污染的来源分析研究中使用的主要方法包括排放清单法,进出质量平衡方法,主成分分析(PCA),正矩阵分解(PMF)模型,等。这些方法主要应用于三个方面:降雨径流污染的来源分析,联合下水道潮湿天气流量(WWF)污染的来源分析,并分析了城市NPS对地表水污染负荷的贡献。源分析方法在城市NPS污染研究中的应用已经证明了从定性到定量的演变,并进一步走向精确量化。这一进展已经从主要依靠现场监测转变为结合模型模拟和采用数学统计分析进行可追溯性。本文回顾了这些原则,优势,缺点,以及这些方法的适用范围。它还旨在解决现有问题并分析潜在的未来发展方向,为后续相关研究提供有价值的参考。
    The contribution of urban non-point source (NPS) pollution to surface water pollution has gradually increased, analyzing the sources of urban NPS pollution is of great significance for precisely controlling surface water pollution. A bibliometric analysis of relevant research literature from 2000 to 2021 reveals that the main methods used in the source analysis research of urban NPS pollution include the emission inventory approach, entry-exit mass balance approach, principal component analysis (PCA), positive matrix factorization (PMF) model, etc. These methods are primarily applied in three aspects: source analysis of rainfall-runoff pollution, source analysis of wet weather flow (WWF) pollution in combined sewers, and analysis of the contribution of urban NPS to the surface water pollution load. The application of source analysis methods in urban NPS pollution research has demonstrated an evolution from qualitative to quantitative, and further towards precise quantification. This progression has transitioned from predominantly relying on on-site monitoring to incorporating model simulations and employing mathematical statistical analyses for traceability. This paper reviews the principles, advantages, disadvantages, and the scope of application of these methods. It also aims to address existing problems and analyze potential future development directions, providing valuable references for subsequent related research.
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  • 文章类型: Journal Article
    随着应对气候变化的紧迫性加剧,探索可持续的负排放技术势在必行。增强风化(EW)代表了一种通过利用岩石风化的自然过程来隔离农田中的大气二氧化碳(CO2)的方法。这篇综述综合了当前EW的研究,专注于其机制,影响因素,以及成功融入农业实践的途径。它评估关键因素,如材料适用性,颗粒大小,应用率,土壤性质,和气候,这对于优化EW的功效至关重要。这项研究强调了电子战的多方面好处,包括土壤肥力的改善,pH调节,和增强的保水性,它们共同有助于提高农业生产力和减缓气候变化。此外,审查介绍了监测,报告,和验证(MRV)和二氧化碳去除(CDR)验证框架是评估和提高EW的有效性和可信度的重要组成部分。通过考察研究现状,提出未来调查的途径,这篇综述旨在加深对EW在可持续农业和气候变化缓解战略中的作用的理解。
    As the urgency to address climate change intensifies, the exploration of sustainable negative emission technologies becomes imperative. Enhanced weathering (EW) represents an approach by leveraging the natural process of rock weathering to sequester atmospheric carbon dioxide (CO2) in agricultural lands. This review synthesizes current research on EW, focusing on its mechanisms, influencing factors, and pathways for successful integration into agricultural practices. It evaluates key factors such as material suitability, particle size, application rates, soil properties, and climate, which are crucial for optimizing EW\'s efficacy. The study highlights the multifaceted benefits of EW, including soil fertility improvement, pH regulation, and enhanced water retention, which collectively contribute to increased agricultural productivity and climate change mitigation. Furthermore, the review introduces Monitoring, Reporting, and Verification (MRV) and Carbon Dioxide Removal (CDR) verification frameworks as essential components for assessing and enhancing EW\'s effectiveness and credibility. By examining the current state of research and proposing avenues for future investigation, this review aims to deepen the understanding of EW\'s role in sustainable agriculture and climate change mitigation strategies.
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  • 文章类型: Meta-Analysis
    目标:肌肉骨骼健康行为和不良事件的变化经常归咎于天气。然而,尽管这种现象得到认可的频率很高,过去的研究在很大程度上是相互矛盾的。这项荟萃分析回顾了,评估和总结病例交叉研究,评估与天气参数(例如温度,相对湿度,空气压力,和降水)。
    方法:对病例交叉研究进行荟萃分析。两名审阅者独立搜索了MEDLINE,EMBASE,CINAHL,WebofScience,Scopus,和PsycINFO从成立到2023年9月10日。已发表的研究采用案例交叉设计来评估肌肉骨骼健康事件的风险(例如症状,住院)与天气参数相关。主要结果是疼痛(新的疼痛或耀斑发作)。纳入研究的质量是根据选择偏差进行评估的,暴露评估,混杂,和结果评估。使用随机效应模型进行结果汇总,并针对每种条件和天气因素分别进行。纳入研究的异质性采用I2方法进行评估。
    结果:在搜索中确定的1,107项研究中,包括11人(15,315名参与者),提供有关28,010个事件(102,536个控制期)的数据,七种肌肉骨骼疾病。汇总分析显示相对湿度之间没有关联,空气压力,温度,或者沉淀和类风湿关节炎的风险,膝盖疼痛或腰痛。高温和低湿度与疼痛增加有关,发红,痛风患者的关节肿胀(赔率:2.04;95%置信区间:1.26至3.30)。
    结论:尽管有患者的轶事报道,天气因素的变化似乎不是类风湿关节炎的危险因素,膝盖,臀部,或者腰痛,但可能对痛风疾病有重大影响。
    OBJECTIVE: The weather is frequently blamed for changes in musculoskeletal health behaviour and adverse events. However, despite the frequency with which this phenomenon is endorsed, past research is largely conflicting. This meta-analysis has reviewed, appraised and summarised case-crossover studies assessing the transient risk of musculoskeletal health events associated with weather parameters (e.g. temperature, relative humidity, air pressure, and precipitation).
    METHODS: A meta-analysis of case-crossover studies was conducted. Two reviewers independently searched MEDLINE, EMBASE, CINAHL, Web of Science, Scopus, and PsycINFO from inception to 10/09/2023. Published studies that employed a case-crossover design to evaluate the risk of musculoskeletal health events (e.g. symptoms, hospitalisation) associated with weather parameters were included. Primary outcome was pain (new episodes of pain or flares). Quality of included studies was assessed based on selection bias, exposure assessment, confounding, and outcome assessment. Pooling of results was conducted using random effects models and separately performed for each condition and weather factor. Heterogeneity among included studies was assessed using I2 measures.
    RESULTS: Of the 1,107 studies identified in the search, 11 were included (15,315 participants), providing data on 28,010 events (102,536 control periods), for seven musculoskeletal conditions. Pooled analyses showed no association between relative humidity, air pressure, temperature, or precipitation and the risk of rheumatoid arthritis, knee pain or low back pain. High temperatures combined with low humidity were associated with increased pain, redness, and joint swelling in people with gout (Odds Ratio: 2.04; 95 % Confidence Interval: 1.26 to 3.30).
    CONCLUSIONS: Despite anecdotal reports from patients, changes in weather factors do not seem to be risk factors for rheumatoid arthritis, knee, hip, or low back pain, but may have a significant influence in gout disease.
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  • 文章类型: Review
    谷热是由吸入关节分生孢子引起的呼吸道疾病,球虫属真菌产生的一种孢子。在干燥中发现,西半球的热生态系统。由于缺乏剂量反应模型和缺乏来自环境样本的定量发生数据,尚未对该疾病进行定量微生物风险评估(QMRA)。进行了文献综述,以收集实验动物给药研究的数据,环境发生,人类疾病爆发,和气象协会。因此,提出了一个风险框架,其中包含了用于参数化球藻的QMRA模型的信息。,提出了八个新的剂量反应模型。对美国西南部农业案例研究进行了概率QMRA,评估与农业职业暴露相关的八种情景。发生ValleyFever的每日工作日风险中位数从2.53×10-7(戴N95面罩时手工种植)到1.33×10-3(不戴面罩时进行机器收获)。文献综述和QMRA合成证实,暴露于雾化的关节分生孢子有可能导致高发作率,但强调环境条件与疾病之间的机制关系仍然知之甚少。为了减少疾病风险,对山谷发烧风险评估研究需求的建议进行了讨论,包括对农民的干预。
    Valley Fever is a respiratory disease caused by inhalation of arthroconidia, a type of spore produced by fungi within the genus Coccidioides spp. which are found in dry, hot ecosystems of the Western Hemisphere. A quantitative microbial risk assessment (QMRA) for the disease has not yet been performed due to a lack of dose-response models and a scarcity of quantitative occurrence data from environmental samples. A literature review was performed to gather data on experimental animal dosing studies, environmental occurrence, human disease outbreaks, and meteorological associations. As a result, a risk framework is presented with information for parameterizing QMRA models for Coccidioides spp., with eight new dose-response models proposed. A probabilistic QMRA was conducted for a Southwestern US agricultural case study, evaluating eight scenarios related to farming occupational exposures. Median daily workday risks for developing severe Valley Fever ranged from 2.53 × 10-7 (planting by hand while wearing an N95 facemask) to 1.33 × 10-3 (machine harvesting while not wearing a facemask). The literature review and QMRA synthesis confirmed that exposure to aerosolized arthroconidia has the potential to result in high attack rates but highlighted that the mechanistic relationships between environmental conditions and disease remain poorly understood. Recommendations for Valley Fever risk assessment research needs in order to reduce disease risks are discussed, including interventions for farmers.
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  • 文章类型: Systematic Review
    疟疾仍然是撒哈拉以南非洲儿童发病和死亡的主要原因,尤其是5岁以下的儿童。为了帮助解决这一挑战,世卫组织建议对某些人群进行化学预防。对于儿童和婴儿,世卫组织建议季节性疟疾化学预防措施(SMC),常年性疟疾化学预防(PMC;以前是婴儿间歇性预防治疗[IPTi]),and,最近,学龄儿童间歇性预防性治疗(IPTsc)。这篇综述描述了上下文因素,包括可行性,可接受性,健康公平,财务考虑,价值观和偏好,影响这些战略的实施。2022年7月5日进行了系统的搜索,并在2023年4月13日重复进行了搜索,以确定相关文献。两名审稿人独立筛选标题的资格,从符合条件的文章中提取数据,并确定和总结了主题。在确定的6,295个独特的标题中,包括65个。最常评估的策略是SMC(n=40),其次是IPTi(n=18),然后是IPTsc(n=6)。总的来说,这些策略是高度可接受的,虽然有了IPTsc,社区关注向育龄女孩提供药物和使用非医务人员分发药物。对于SMC,送货上门带来了更高的覆盖率,改善护理人员的接受度,并降低成本。当护理人员被指控在没有监督的情况下给予剂量2和3时,注意到较低的依从性。对于SMC和IPTi,旅行距离和恶劣天气限制了可访问性。宣传和照顾者教育工作,保留高质量的药品分销商,改善交通是提高覆盖率的关键。需要更多的研究来了解社区价值观和偏好在化学预防实施中的作用。
    Malaria remains a leading cause of childhood morbidity and mortality in sub-Saharan Africa, particularly among children under 5 years of age. To help address this challenge, the WHO recommends chemoprevention for certain populations. For children and infants, the WHO recommends seasonal malaria chemoprevention (SMC), perennial malaria chemoprevention (PMC; formerly intermittent preventive treatment in infants [IPTi]), and, more recently, intermittent preventive treatment in school children (IPTsc). This review describes the contextual factors, including feasibility, acceptability, health equity, financial considerations, and values and preferences, that impact implementation of these strategies. A systematic search was conducted on July 5, 2022, and repeated April 13, 2023, to identify relevant literature. Two reviewers independently screened titles for eligibility, extracted data from eligible articles, and identified and summarized themes. Of 6,295 unique titles identified, 65 were included. The most frequently evaluated strategy was SMC (n = 40), followed by IPTi (n = 18) and then IPTsc (n = 6). Overall, these strategies were highly acceptable, although with IPTsc, there were community concerns with providing drugs to girls of reproductive age and the use of nonmedical staff for drug distribution. For SMC, door-to-door delivery resulted in higher coverage, improved caregiver acceptance, and reduced cost. Lower adherence was noted when caregivers were charged with giving doses 2 and 3 unsupervised. For SMC and IPTi, travel distances and inclement weather limited accessibility. Sensitization and caregiver education efforts, retention of high-quality drug distributors, and improved transportation were key to improving coverage. Additional research is needed to understand the role of community values and preferences in chemoprevention implementation.
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